Autoimmune regulator is acetylated by transcription coactivator CBP/p300. (Q39338215)

11 September 2017

Autoimmune regulator is acetylated by transcription coactivator CBP/p300. (English)

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11 September 2017

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11 September 2017

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11 September 2017

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Ana Rebane

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Mario Saare

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Mario Saare

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1

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author name string

Balaji Rajashekar

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3

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PubMed ID

22659170

11 September 2017

language of work or name

English

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publication date

30 May 2012

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Experimental Cell Research

11 September 2017

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11 September 2017

318

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11 September 2017

14

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11 September 2017

1767-1778

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Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.

11 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Projection of an immunological self shadow within the thymus by the aire protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Aire regulates negative selection of organ-specific T cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

APECED: a monogenic autoimmune disease providing new clues to self-tolerance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

The monopartite nuclear localization signal of autoimmune regulator mediates its nuclear import and interaction with multiple importin alpha molecules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Positional cloning of the APECED gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Localization of the APECED protein in distinct nuclear structures

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Cooperative activation of transcription by autoimmune regulator AIRE and CBP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

CREB-binding protein and p300 in transcriptional regulation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Acetylation and deacetylation of non-histone proteins

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Control of Smad7 stability by competition between acetylation and ubiquitination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor α

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Regulation of E2F1 activity by acetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Regulation of transcription factor YY1 by acetylation and deacetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Coordination of a transcriptional switch by HMGI(Y) acetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Bromodomain: an acetyl-lysine binding domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

TiGER: a database for tissue-specific gene expression and regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

CROC: finding chromosomal clusters in eukaryotic genomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Nuclear DEAF-1-related (NUDR) protein contains a novel DNA binding domain and represses transcription of the heterogeneous nuclear ribonucleoprotein A2/B1 promoter.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Mapping DNA-binding domains of the autoimmune regulator protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

APECED-causing mutations in AIRE reveal the functional domains of the protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Acetylation of p53 inhibits its ubiquitination by Mdm2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Acetylation mimics within individual core histone tail domains indicate distinct roles in regulating the stability of higher-order chromatin structure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Lysine acetylation targets protein complexes and co-regulates major cellular functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

AIRE activated tissue specific genes have histone modifications associated with inactive chromatin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Chromosomal clustering of genes controlled by the aire transcription factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Regulation of cellular metabolism by protein lysine acetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Regulation of protein turnover by acetyltransferases and deacetylases.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

Deletional tolerance mediated by extrathymic Aire-expressing cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.013

10.1016/J.YEXCR.2012.04.013

7 January 2021

Identifiers

DOI

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11 September 2017

1 reference

PubMed ID

22659170