Allosteric conversation in the androgen receptor ligand-binding domain surfaces. (Q39338812)

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2 February 2020

title

Allosteric conversation in the androgen receptor ligand-binding domain surfaces (English)

1 reference

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2 February 2020

1 reference

4

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2 February 2020

Charlotte Bevan

7

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2 February 2020

Eva Estébanez-Perpiñá

9

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2 February 2020

Juan Fernández-Recio

10

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2 February 2020

author name string

Solène Grosdidier

1

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2 February 2020

Laia R Carbó

2

1 reference

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2 February 2020

Víctor Buzón

3

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2 February 2020

Phuong Nguyen

5

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2 February 2020

John D Baxter

6

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2 February 2020

Paul Webb

8

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2 February 2020

publication date

31 May 2012

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2 February 2020

published in

Molecular Endocrinology

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2 February 2020

volume

26

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2 February 2020

page(s)

1078-1090

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2 February 2020

issue

7

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Structural basis of coactivation of liver receptor homolog-1 by -catenin

2 February 2020

cites work

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Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

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Structural basis for antagonism and resistance of bicalutamide in prostate cancer

11 September 2017

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The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor

11 September 2017

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Recognition and accommodation at the androgen receptor coactivator binding interface

11 September 2017

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Nuclear receptors and disease: androgen receptor

11 September 2017

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Mutation scanning of the androgen receptor gene in patients with psychiatric disorders reveals highly conserved variants in alcoholic and phobia patients.

11 September 2017

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Mutation of the androgen receptor (R840S) in an Egyptian patient with partial androgen insensitivity syndrome: review of the literature on the clinical expression of different R840 substitutions

11 September 2017

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Molecular biology of the androgen receptor

11 September 2017

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The amino terminus of the human AR is target for corepressor action and antihormone agonism

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Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function

11 September 2017

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Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

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Substitution of arginine-839 by cysteine or histidine in the androgen receptor causes different receptor phenotypes in cultured cells and coordinate degrees of clinical androgen resistance

11 September 2017

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11 September 2017

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11 September 2017

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Domains of the Human Androgen Receptor Involved in Steroid Binding, Transcriptional Activation, and Subcellular Localization

11 September 2017

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11 September 2017

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A novel mutation F826L in the human androgen receptor in partial androgen insensitivity syndrome; increased NH2-/COOH-terminal domain interaction and TIF2 co-activation.

11 September 2017

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The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor

14 September 2017

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Endocrine-Induced Regression of Cancers

14 September 2017

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TR surfaces and conformations required to bind nuclear receptor corepressor

14 September 2017

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Participation of critical residues from the extreme C-terminal end of the human androgen receptor in the ligand binding function

25 September 2017

1 reference

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Human androgen receptor mutation disrupts ternary interactions between ligand, receptor domains, and the coactivator TIF2 (transcription intermediary factor 2).

25 September 2017

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FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor

25 September 2017

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Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol

25 September 2017

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Perspectives on designs of antiandrogens for prostate cancer.

25 September 2017

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21 August 2018

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An interpretation of positional displacement of the helix12 in nuclear receptors: preexistent swing-up motion triggered by ligand binding

21 August 2018

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Structural dynamics of the human androgen receptor: implications for prostate cancer and neurodegenerative disease.

21 August 2018

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Partial androgen insensitivity syndrome with R840H mutation in androgen receptor: report of one case

21 August 2018

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Novel and recurrent mutations in patients with androgen insensitivity syndromes.

21 August 2018

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Partial androgen insensitivity with phenotypic variation caused by androgen receptor mutations that disrupt activation function 2 and the NH(2)- and carboxyl-terminal interaction.

21 August 2018

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Germline mutation analysis of the androgen receptor gene in Finnish patients with prostate cancer.

21 August 2018

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Pattern of somatic androgen receptor gene mutations in patients with hormone-refractory prostate cancer

21 August 2018

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Functional analysis of 44 mutant androgen receptors from human prostate cancer.

21 August 2018

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Androgen receptor mutations causing human androgen insensitivity syndromes show a key role of residue M807 in Helix 8-Helix 10 interactions and in receptor ligand-binding domain stability

21 August 2018

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Androgen receptor mutations in prostate cancer.

21 August 2018

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Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system

21 August 2018

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The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate.

21 August 2018

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R726L androgen receptor mutation is uncommon in prostate cancer families in the united states

21 August 2018

1 reference

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A 629RKLKK633 motif in the hinge region controls the androgen receptor at multiple levels

2 December 2018

1 reference

12 December 2020

Characterization of the two coactivator-interacting surfaces of the androgen receptor and their relative role in transcriptional control

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12 December 2020

Collocation of androgen receptor gene mutations in prostate cancer

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12 December 2020

Single amino acid substitution (840Arg-->His) in the hormone-binding domain of the androgen receptor leads to incomplete androgen insensitivity syndrome associated with a thermolabile androgen receptor

1 reference

12 December 2020

Ligand- and coactivator-mediated transactivation function (AF2) of the androgen receptor ligand-binding domain is inhibited by the cognate hinge region

1 reference

12 December 2020

Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine

1 reference

12 December 2020

A novel point mutation (R840S) in the androgen receptor in a Brazilian family with partial androgen insensitivity syndrome

1 reference

12 December 2020

Two percent of Finnish prostate cancer patients have a germ-line mutation in the hormone-binding domain of the androgen receptor gene

1 reference

12 December 2020

Androgen insensitivity syndromes

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12 December 2020

Androgen receptor gene alterations and chromosomal gains and losses in prostate carcinomas appearing during finasteride treatment for benign prostatic hyperplasia

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12 December 2020

A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1)

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12 December 2020

Molecular defects of the androgen receptor

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12 December 2020

Identifiers

DOI

10.1210/ME.2011-1281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22653923%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22653923%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22653923%20AND%20SRC:MED&resulttype=core&format=json