Parkin co-regulated gene is involved in aggresome formation and autophagy in response to proteasomal impairment (Q39339034)

11 September 2017

Parkin co-regulated gene is involved in aggresome formation and autophagy in response to proteasomal impairment (English)

1 reference

11 September 2017

0 references

Paul J Lockhart

3

0 references

author name string

Juliet M Taylor

series ordinal

1

1 reference

PubMed ID

22652456

11 September 2017

Kate M Brody

series ordinal

2

1 reference

PubMed ID

22652456

11 September 2017

language of work or name

English

0 references

publication date

28 May 2012

1 reference

Experimental Cell Research

11 September 2017

1 reference

11 September 2017

318

1 reference

11 September 2017

16

1 reference

11 September 2017

2059-2070

1 reference

Genetics of Parkinson disease: paradigm shifts and future prospects.

11 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkinson's disease. First of two parts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Ubiquitin-mediated proteolysis: biological regulation via destruction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Aggresomes, inclusion bodies and protein aggregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

RING finger 1 mutations in Parkin produce altered localization of the protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Aggresome formation and neurodegenerative diseases: therapeutic implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Identification of a novel gene linked to parkin via a bi-directional promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell Death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Susceptibility to leprosy is associated with PARK2 and PACRG.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin stabilizes microtubules through strong binding mediated by three independent domains.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Impairment of the ubiquitin-proteasome system by protein aggregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Emerging role for autophagy in the removal of aggresomes in Schwann cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Fine structure of the autophagosome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Oxidative stress impairs the heat stress response and delays unfolded protein recovery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Intracellular protein catabolism and its control during nutrient deprivation and supply

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

TOR, a central controller of cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Methods for monitoring autophagy from yeast to human

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Analysis of PArkin Co-Regulated Gene in a Taiwanese-ethnic Chinese cohort with early-onset Parkinson's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

The UBL domain of PLIC-1 regulates aggresome formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

A critical role for CHIP in the aggresome pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin-co-regulated gene (PACRG) product interacts with tubulin and microtubules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Characterization of chronic low-level proteasome inhibition on neural homeostasis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Loss of autophagy in the central nervous system causes neurodegeneration in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Autophagy in health and disease: a double-edged sword

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Parkin interacts with Ambra1 to induce mitophagy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.05.011

10.1016/J.YEXCR.2012.05.011

7 January 2021

Identifiers

DOI

1 reference

11 September 2017

1 reference

PubMed ID

22652456