Parkin interacts with Ambra1 to induce mitophagy (Q24313512)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903599

ubiquitin protein ligase binding

1 reference

Autophagy/beclin 1 regulator 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Kris Gevaert

5

0 references

Bart De Strooper

6

object named as

Bart De Strooper

0 references

author name string

Cindy Van Humbeeck

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

Tom Cornelissen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

Hilde Hofkens

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

Wim Mandemakers

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

Wim Vandenberghe

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

Kris Gevaert

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

Bart De Strooper

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

language of work or name

English

0 references

publication date

13 July 2011

0 references

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

issue

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

page(s)

10249-10261

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

describes a project that uses

15 May 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6623066/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

12 December 2020

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

1 reference

12 December 2020

Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation

1 reference

12 December 2020

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

1 reference

12 December 2020

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation

1 reference

12 December 2020

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

1 reference

12 December 2020

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

1 reference

12 December 2020

A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell Death

1 reference

12 December 2020

Alterations in the common fragile site gene Parkin in ovarian and other cancers

1 reference

12 December 2020

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

1 reference

12 December 2020

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

1 reference

12 December 2020

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

1 reference

12 December 2020

Parkin stabilizes microtubules through strong binding mediated by three independent domains.

1 reference

12 December 2020

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

12 December 2020

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

12 December 2020

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

1 reference

12 December 2020

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

1 reference

12 December 2020

Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity

1 reference

12 December 2020

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

1 reference

12 December 2020

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

1 reference

12 December 2020

Culturing hippocampal neurons

1 reference

12 December 2020

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

12 December 2020

Ambra1 regulates autophagy and development of the nervous system

1 reference

12 December 2020

Parkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain

1 reference

12 December 2020

Mapping multiprotein complexes by affinity purification and mass spectrometry

1 reference

12 December 2020

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

1 reference

12 December 2020

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

1 reference

12 December 2020

Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome

1 reference

12 December 2020

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

1 reference

12 December 2020

1 reference

12 December 2020

Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function

1 reference

12 December 2020

In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography

1 reference

12 December 2020

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

1 reference

12 December 2020

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

1 reference

12 December 2020

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

1 reference

12 December 2020

PINK1 gene knockdown leads to increased binding of parkin with actin filament

1 reference

12 December 2020

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

1 reference

12 December 2020

Mammalian autophagy: core molecular machinery and signaling regulation

1 reference

12 December 2020

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

1 reference

12 December 2020

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

1 reference

12 December 2020

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

1 reference

12 December 2020

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

1 reference

12 December 2020

The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

1 reference

12 December 2020

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

1 reference

12 December 2020

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

1 reference

12 December 2020

Mitochondria supply membranes for autophagosome biogenesis during starvation

1 reference

12 December 2020

Network organization of the human autophagy system

1 reference

12 December 2020

Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming

1 reference

12 December 2020

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

1 reference

12 December 2020

The role of autophagy during development in higher eukaryotes

1 reference

12 December 2020

The origin of the autophagosomal membrane

1 reference

12 December 2020

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

1 reference

12 December 2020

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

1 reference

12 December 2020

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

1 reference

12 December 2020

Small pH gradients inhibit cytochrome c oxidase: implications for H+ entry to the binuclear center

1 reference

12 December 2020

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

12 December 2020

10.1523/JNEUROSCI.1917-11.2011

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

4406974

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

4406974

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6623066&resulttype=core&format=json

15 May 2020

PubMed publication ID

21753002

2 references

Consolidated OpenCitations Corpus – April 2017

4406974