USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6. (Q39345375)

11 September 2017

USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6. (English)

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11 September 2017

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Xiao He

1

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11 September 2017

Yi Li

2

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11 September 2017

Chao Li

3

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11 September 2017

Li-Juan Liu

4

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11 September 2017

Xiao-Dong Zhang

5

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11 September 2017

Yu Liu

6

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11 September 2017

Hong-Bing Shu

7

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11 September 2017

19 May 2012

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Journal of Molecular Cell Biology

11 September 2017

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11 September 2017

5

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11 September 2017

39-47

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11 September 2017

1

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Ubiquitin-mediated activation of TAK1 and IKK.

11 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Signalling pathways of the TNF superfamily: a double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

MdmX is a substrate for the deubiquitinating enzyme USP2a

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Ubiquitylation in innate and adaptive immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Ubiquitin in NF-kappaB signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Nod-like proteins in immunity, inflammation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Expanding TRAF function: TRAF3 as a tri-faced immune regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

21 January 2018

Signaling to NF-kappaB

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https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Shared principles in NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Signaling to NF-kappaB by Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The roles of TLRs, RLRs and NLRs in pathogen recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Crystallographic analysis of CD40 recognition and signaling by human TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

An RNAi screen identifies USP2 as a factor required for TNF-α-induced NF-κB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

A genomic and functional inventory of deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Structural basis for self-association and receptor recognition of human TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The isopeptidase USP2a protects human prostate cancer from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Genetic knockouts and knockins in human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Suppression of cancer cell growth by promoting cyclin D1 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The novel functions of ubiquitination in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The TRAF6 RING finger domain mediates physical interaction with Ubc13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Distinct molecular mechanism for initiating TRAF6 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

E2 interaction and dimerization in the crystal structure of TRAF6

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJS024

21 January 2018

Identifiers

DOI

10.1093/JMCB/MJS024

1 reference

11 September 2017

1 reference