β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer (Q39345531)

11 September 2017

title

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer (English)

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11 September 2017

author

Josep Tabernero Caturla

18

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11 September 2017

20

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11 September 2017

Oriol Arqués

5

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Paloma Ordóñez-Morán

Paloma Ordóñez-Morán

2

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Isabel Puig

Isabel Puig

3

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Stefania Landolfi

Stefania Landolfi

6

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José R Herance

José Raúl Herance

8

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Joan Domingo Gispert

Juan D Gispert

9

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Santiago Ramon y Cajal

Santiago Ramón y Cajal

12

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author name string

Stephan P Tenbaum

1

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11 September 2017

Irene Chicote

4

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11 September 2017

Yolanda Fernández

7

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11 September 2017

Leire Mendizabal

10

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11 September 2017

Susana Aguilar

11

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11 September 2017

Simó Schwartz

13

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11 September 2017

Ana Vivancos

14

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11 September 2017

Eloy Espín

15

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11 September 2017

Santiago Rojas

16

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11 September 2017

José Baselga

17

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11 September 2017

Alberto Muñoz

19

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11 September 2017

language of work or name

English

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publication date

1 June 2012

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11 September 2017

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11 September 2017

volume

18

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11 September 2017

issue

6

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11 September 2017

page(s)

892-901

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11 September 2017

cites work

Global cancer statistics

1 reference

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

Wnt signalling in stem cells and cancer

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1 reference

Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.

21 January 2018

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Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination

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The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis

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Functional interaction between beta-catenin and FOXO in oxidative stress signaling

21 January 2018

1 reference

21 January 2018

1 reference

Stressing the role of FoxO proteins in lifespan and disease

21 January 2018

1 reference

The emerging roles of forkhead box (Fox) proteins in cancer

21 January 2018

1 reference

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1.

21 January 2018

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Genetic prognostic and predictive markers in colorectal cancer

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Recent developments in anti-cancer agents targeting PI3K, Akt and mTORC1/2.

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

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Targeting the phosphoinositide 3-kinase pathway in cancer

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Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

21 January 2018

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

21 January 2018

1 reference

Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity

21 January 2018

1 reference

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

21 January 2018

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Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

21 January 2018

1 reference

Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression

21 January 2018

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A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

21 January 2018

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IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos.

21 January 2018

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Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development.

21 January 2018

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Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

21 January 2018

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

21 January 2018

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer

21 January 2018

1 reference

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

21 January 2018

1 reference

Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT

21 January 2018

1 reference

Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer

21 January 2018

1 reference

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

21 January 2018

1 reference

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

1 reference

Tangled webs: evidence of cross-talk between c-Raf-1 and Akt.

21 January 2018

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Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

21 January 2018

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Resist or die: FOXO transcription factors determine the cellular response to chemotherapy.

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FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells

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FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation

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FADD: a regulator of life and death

21 January 2018

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Heterogeneity in cancer: cancer stem cells versus clonal evolution

21 January 2018

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Wnt/beta-catenin signaling in cancer stemness and malignant behavior

21 January 2018

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The cancer stem cell: premises, promises and challenges

21 January 2018

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

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Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

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Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

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The Intestinal Wnt/TCF Signature.

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Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites.

21 January 2018

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Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer.

21 January 2018

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SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity.

21 January 2018

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

21 January 2018

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Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis

21 January 2018

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Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector

21 January 2018

1 reference

Lentiviral vectors to probe and manipulate the Wnt signaling pathway

21 January 2018

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Chemoprevention of colorectal cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22610277

12 December 2020

inferred from PubMed ID database lookup

Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22610277

12 December 2020

inferred from PubMed ID database lookup

Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22610277

12 December 2020

inferred from PubMed ID database lookup

Colon cancer stem cells

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.2772

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Dimensions Publication ID

11 September 2017

1006547486

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