Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone (Q34420112)

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English	Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone	scientific article

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scholarly article

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Europe PubMed Central

2 August 2017

Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone (English)

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Europe PubMed Central

2 August 2017

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ChEBI release 2020-05-28

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15

object named as

Larry W Kwak

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2 August 2017

author name string

Yuhuan Zheng

1

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Europe PubMed Central

2 August 2017

Jing Yang

2

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Europe PubMed Central

2 August 2017

Jianfei Qian

3

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Europe PubMed Central

2 August 2017

Liang Zhang

4

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Europe PubMed Central

2 August 2017

Yong Lu

5

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Europe PubMed Central

2 August 2017

Haiyan Li

6

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Europe PubMed Central

2 August 2017

Heather Lin

7

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Europe PubMed Central

2 August 2017

Yongsheng Lan

8

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Europe PubMed Central

2 August 2017

Zhiqiang Liu

9

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Europe PubMed Central

2 August 2017

Jin He

10

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Europe PubMed Central

2 August 2017

Sungyoul Hong

11

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Europe PubMed Central

2 August 2017

Sheeba Thomas

12

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Europe PubMed Central

2 August 2017

Jatin Shah

13

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2 August 2017

Veera Baladandayuthapani

14

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2 August 2017

Qing Yi

16

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2 August 2017

publication date

30 December 2011

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2 August 2017

Journal of Molecular Medicine

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2 August 2017

90

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2 August 2017

6

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2 August 2017

695-706

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Europe PubMed Central

2 August 2017

https://scigraph.springernature.com/pub.10.1007/s00109-011-0849-9

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Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human

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6 July 2018

CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.

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6 July 2018

The current status and future of multiple myeloma in the clinic

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6 July 2018

Current multiple myeloma treatment strategies with novel agents: a European perspective

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6 July 2018

Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis

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6 July 2018

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

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Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.

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Cancer statistics, 2009

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Treatment of relapsed/refractory multiple myeloma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

The role of the bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Improved survival in multiple myeloma and the impact of novel therapies

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Targeting the phosphatidylinositol 3-kinase pathway in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins

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6 July 2018

Interaction index and different methods for determining drug interaction in combination therapy

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6 July 2018

Targeting beta2-microglobulin for induction of tumor apoptosis in human hematological malignancies

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6 July 2018

Phosphoinositides in cell regulation and membrane dynamics

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Multiple myeloma.

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6 July 2018

The magnitude of Akt/phosphatidylinositol 3'-kinase proliferating signaling is related to CD45 expression in human myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Drug resistance and drug development in multiple myeloma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis

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6 July 2018

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

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6 July 2018

Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma

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6 July 2018

Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212830

6 July 2018

Bim: a novel member of the Bcl-2 family that promotes apoptosis

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6 July 2018

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

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21 January 2018

Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses

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https://api.crossref.org/works/10.1007%2FS00109-011-0849-9

21 January 2018

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

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21 January 2018

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10.1007/S00109-011-0849-9

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Europe PubMed Central

2 August 2017

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Europe PubMed Central

2 August 2017

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Europe PubMed Central

2 August 2017

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