Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells (Q39360179)

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English	Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 September 2017

Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

apoptotic process

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author name string

Hye-Sook Seo

1

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Europe PubMed Central

PubMed publication ID

11 September 2017

Han-Seok Choi

2

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11 September 2017

Soon-Re Kim

3

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PubMed publication ID

11 September 2017

Youn Kyung Choi

4

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PubMed publication ID

11 September 2017

Sang-Mi Woo

5

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11 September 2017

Incheol Shin

6

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PubMed publication ID

11 September 2017

Jong-Kyu Woo

7

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Europe PubMed Central

PubMed publication ID

11 September 2017

Sang-Yoon Park

8

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PubMed publication ID

11 September 2017

Yong Cheol Shin

9

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11 September 2017

Seong-Gyu Ko

10

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11 September 2017

publication date

20 April 2012

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11 September 2017

Molecular and Cellular Biochemistry

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11 September 2017

366

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11 September 2017

1-2

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11 September 2017

319-334

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PubMed publication ID

11 September 2017

Biochemical and morphological events during okadaic acid-induced apoptosis of Tsc2-null ERC-18 cell line

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Cell death induced by the Fas/Fas ligand pathway and its role in pathology

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Smac: Its role in apoptosis induction and use in lung cancer diagnosis and treatment

1 reference

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21 January 2018

Mechanisms of apoptosis induced by anticancer compounds in melanoma cells

1 reference

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21 January 2018

Phytoestrogens: end of a tale?

1 reference

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Contaminants in human milk: weighing the risks against the benefits of breastfeeding

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21 January 2018

Do phytoestrogens reduce the risk of breast cancer and breast cancer recurrence? What clinicians need to know

1 reference

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21 January 2018

Phytoestrogens: Potential Benefits and Implications for Breast Cancer Survivors

1 reference

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21 January 2018

Implications of phytoestrogen intake for breast cancer

1 reference

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21 January 2018

Clinical pharmacology of isoflavones and its relevance for potential prevention of prostate cancer

1 reference

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21 January 2018

Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis

1 reference

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21 January 2018

DNA methylation and soy phytoestrogens: quantitative study in DU-145 and PC-3 human prostate cancer cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Induction of apoptotic cell death by phytoestrogens by up-regulating the levels of phospho-p53 and p21 in normal and malignant estrogen receptor α-negative breast cells

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Evaluation of the effects of the flavonoid apigenin on apoptotic pathway gene expression on the colon cancer cell line (HT29).

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

her-2 upstream open reading frame effects on the use of downstream initiation codons

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

HER2-targeted therapy in breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Biologic and therapeutic role of HER2 in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Elevated serum Her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Trastuzumab and breast cancer: developments and current status

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Her2-positive breast cancer: herceptin and beyond.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Expression of active Akt protects against tamoxifen-induced apoptosis in MCF-7 Cells

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

p53-dependent apoptosis pathways.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Role of the p53-homologue p73 in E2F1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

p53 and E2f: partners in life and death

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Targeting STAT3 affects melanoma on multiple fronts

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Activation of stat3 in human melanoma promotes brain metastasis

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Resultant effects on cell proliferation

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

NF-κB and STAT3 - key players in liver inflammation and cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Mechanisms of trastuzumab resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

Role of biologic therapy and chemotherapy in hormone receptor- and HER2-positive breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11010-012-1310-2

21 January 2018

NF-κB and cancer: a paradigm of Yin-Yang.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of p53-dependent apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apigenin induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax- and Bcl-2-triggered mitochondrial pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MCF-7 breast carcinoma cells do not express caspase-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phytoestrogens and breast cancer prevention: possible mechanisms of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soybeans, Soy Foods, Isoflavones and Risk of Colorectal Cancer: a Review of Experimental and Epidemiological Data

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22527937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11010-012-1310-2

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

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