Attenuation of PTEN perturbs genomic stability via activation of Akt and down-regulation of Rad51 in human embryonic kidney cells (Q39367212)

11 September 2017

title

Attenuation of PTEN perturbs genomic stability via activation of Akt and down-regulation of Rad51 in human embryonic kidney cells (English)

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11 September 2017

Ananda Mukherjee

1

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11 September 2017

Parimal Karmakar

series ordinal

2

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11 September 2017

publication date

4 April 2012

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11 September 2017

published in

Molecular Carcinogenesis

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11 September 2017

volume

52

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11 September 2017

issue

8

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11 September 2017

page(s)

611-618

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

11 September 2017

cites work

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

21 January 2018

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Essential role for nuclear PTEN in maintaining chromosomal integrity

21 January 2018

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Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.

21 January 2018

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Lack of PTEN sequesters CHK1 and initiates genetic instability.

21 January 2018

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

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Pten dose dictates cancer progression in the prostate

21 January 2018

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

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Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells

21 January 2018

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Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway

21 January 2018

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

21 January 2018

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Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation

21 January 2018

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Inactivation of PTEN is responsible for the survival of Hep G2 cells in response to etoposide-induced damage

21 January 2018

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Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis

21 January 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

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A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle

21 January 2018

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Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MC.21903

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11 September 2017

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