TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry. (Q39370899)

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English	TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry.	scientific article

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27 January 2020

TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry (English)

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27 January 2020

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Christian J. Leumann

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27 January 2020

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Sue Murray

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27 January 2020

Damian Ittig

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27 January 2020

Erich Koller

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27 January 2020

Andres Berdeja

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27 January 2020

Alfred Chappell

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27 January 2020

Thazha P Prakash

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27 January 2020

Michaela Norrbom

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27 January 2020

Eric E Swayze

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27 January 2020

Punit P Seth

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27 January 2020

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30 March 2012

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27 January 2020

Nucleic Acids Research

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27 January 2020

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27 January 2020

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27 January 2020

6135-6143

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27 January 2020

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Creative Commons Attribution-NonCommercial 3.0 Unported

4 October 2016

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Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

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11 September 2017

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

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An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

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RNAi and small interfering RNAs in human disease therapeutic applications

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Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes

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Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

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Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.

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Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

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RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform

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11 September 2017

LNA-mediated microRNA silencing in non-human primates

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2'-Modified oligonucleotides for antisense therapeutics

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Silencing of microRNAs in vivo with 'antagomirs'

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Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA

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Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor

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DNA analogues: from supramolecular principles to biological properties

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Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides

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Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

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11 September 2017

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

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Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models

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Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals

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Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection

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Watson-Crick base-pairing properties of tricyclo-DNA.

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21 August 2018

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21 August 2018

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Contributions of dangling end stacking and terminal base-pair formation to the stabilities of XGGCCp, XCCGGp, XGGCCYp, and XCCGGYp helixes

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https://pubmed.ncbi.nlm.nih.gov/22467214

12 December 2020

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10.1093/NAR/GKS273

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27 January 2020

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27 January 2020

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