Novel multiple apoptotic mechanism of shikonin in human glioma cells (Q39374292)

11 September 2017

Novel multiple apoptotic mechanism of shikonin in human glioma cells (English)

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11 September 2017

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Ching-Hsein Chen

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11 September 2017

Miao-Ling Lin

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2

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11 September 2017

Ping-Lin Ong

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3

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11 September 2017

Jen-Tsung Yang

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4

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11 September 2017

24 March 2012

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Annals of Surgical Oncology

11 September 2017

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11 September 2017

19

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11 September 2017

9

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11 September 2017

3097-3106

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https://scigraph.springernature.com/pub.10.1245/s10434-012-2324-4

11 September 2017

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Physical stability of shikonin derivatives from the roots of Lithospermum erythrorhizon cultivated in Korea.

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Involvement of reactive oxygen species, but not mitochondrial permeability transition in the apoptotic induction of human SK-Hep-1 hepatoma cells by shikonin

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Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappaB pathway

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Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells

21 January 2018

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Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis

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p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells

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p53 has a direct apoptogenic role at the mitochondria

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Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation.

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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Expression of p53 and prognosis in children with malignant gliomas.

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O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

21 January 2018

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10.1245/S10434-012-2324-4

21 January 2018

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11 September 2017

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