Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma (Q39376909)

11 September 2017

title

Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma (English)

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11 September 2017

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J Liu

1

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11 September 2017

X Cheng

2

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11 September 2017

Y Zhang

3

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11 September 2017

S Li

4

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11 September 2017

H Cui

5

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11 September 2017

L Zhang

6

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11 September 2017

R Shi

7

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11 September 2017

Z Zhao

8

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11 September 2017

C He

9

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11 September 2017

C Wang

10

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11 September 2017

H Zhao

11

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11 September 2017

C Zhang

12

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11 September 2017

H A Fisk

13

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11 September 2017

T M Guadagno

14

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11 September 2017

Y Cui

15

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11 September 2017

language of work or name

English

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publication date

19 March 2012

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11 September 2017

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11 September 2017

volume

32

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11 September 2017

issue

6

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11 September 2017

page(s)

713-723

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

11 September 2017

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The cohesin ring concatenates sister DNA molecules

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Oncogenic B-Raf(V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells

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Oncogenes and tumour suppressors take on centrosomes

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Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

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Antizyme restrains centrosome amplification by regulating the accumulation of Mps1 at centrosomes

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Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

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Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

21 January 2018

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Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.

21 January 2018

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Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex

21 January 2018

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Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

21 January 2018

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Phosphoregulation of human Mps1 kinase

21 January 2018

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Mps1 activation loop autophosphorylation enhances kinase activity.

21 January 2018

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Preventing the degradation of mps1 at centrosomes is sufficient to cause centrosome reduplication in human cells

21 January 2018

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Mps1 as a link between centrosomes and genomic instability

21 January 2018

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Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases

21 January 2018

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Mps1 phosphorylation sites regulate the function of centrin 2 in centriole assembly

21 January 2018

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B-Raf(V600E) signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells

21 January 2018

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Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint

21 January 2018

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Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

21 January 2018

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Centriole assembly and the role of Mps1: defensible or dispensable?

21 January 2018

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Proteomic characterization of the human centrosome by protein correlation profiling

21 January 2018

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

21 January 2018

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Mechanism limiting centrosome duplication to once per cell cycle

21 January 2018

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The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila.

21 January 2018

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Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

21 January 2018

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Anaphase inactivation of the spindle checkpoint

21 January 2018

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Mps1 phosphorylation by MAP kinase is required for kinetochore localization of spindle-checkpoint proteins

31 March 2020

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Activity and regulation of the centrosome-associated proteasome

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.94

Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.94

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.94

1 reference

11 September 2017

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