Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines (Q39380247)

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scientific article published on 14 March 2012

Language	Label	Description	Also known as
English	Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines	scientific article published on 14 March 2012

Statements

scholarly article

1 reference

Europe PubMed Central

11 September 2017

Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines (English)

1 reference

Europe PubMed Central

11 September 2017

author name string

Z X Meng

1

1 reference

Europe PubMed Central

11 September 2017

Y Yin

2

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Europe PubMed Central

11 September 2017

J H Lv

3

1 reference

Europe PubMed Central

11 September 2017

M Sha

4

1 reference

Europe PubMed Central

11 September 2017

Y Lin

5

1 reference

Europe PubMed Central

11 September 2017

L Gao

6

1 reference

Europe PubMed Central

11 September 2017

Y X Zhu

7

1 reference

Europe PubMed Central

11 September 2017

Y J Sun

8

1 reference

Europe PubMed Central

11 September 2017

X Han

9

1 reference

Europe PubMed Central

11 September 2017

publication date

14 March 2012

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

55

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Europe PubMed Central

11 September 2017

6

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Europe PubMed Central

11 September 2017

1733-1744

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Europe PubMed Central

11 September 2017

https://scigraph.springernature.com/pub.10.1007/s00125-012-2516-2

0 references

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Functional and molecular defects of pancreatic islets in human type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Islet beta cell failure in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Triggering and amplifying pathways of regulation of insulin secretion by glucose

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Cholesterol in islet dysfunction and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Putative metabolic effects of the liver X receptor (LXR).

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

The nuclear receptor LXR is a glucose sensor

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Liver x receptors: potential novel targets in cardiovascular diseases

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Beta-cell lipotoxicity: burning fat into heat?

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

A simplified system for generating recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Cell death and impairment of glucose-stimulated insulin secretion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the beta-cell line INS-1E.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1).

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2516-2

21 January 2018

Sweet dreams for LXR

1 reference

https://pubmed.ncbi.nlm.nih.gov/22415588

12 December 2020

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Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22415588

12 December 2020

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Plasma oxysterols and tocopherol in patients with diabetes mellitus and hyperlipidemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22415588

12 December 2020

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Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus

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https://pubmed.ncbi.nlm.nih.gov/22415588

12 December 2020

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The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population

1 reference

https://pubmed.ncbi.nlm.nih.gov/22415588

12 December 2020

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Pathogenesis of type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22415588

12 December 2020

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Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22415588

12 December 2020

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Liver X receptors as potential therapeutic targets for multiple diseases.

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Identifiers

10.1007/S00125-012-2516-2

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

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