New perspectives into the molecular pathogenesis and treatment of type 2 diabetes (Q28203726)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11239409%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

review article

1 reference

title

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11239409%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11239409%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

author name string

A R Saltiel

series ordinal

1

0 references

language of work or name

English

0 references

publication date

1 February 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11239409%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11239409%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

volume

104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11239409%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

page(s)

517-529

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11239409%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11239409%20AND%20SRC:MED&resulttype=core&format=json

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

5 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

PPAR gamma is required for placental, cardiac, and adipose tissue development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Free fatty acids and pathogenesis of type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Mechanisms of fatty acid-induced inhibition of glucose uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Role of brain insulin receptor in control of body weight and reproduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Signaling mechanisms that regulate glucose transport

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Glucagon-like Peptide 2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Obesity in the new millennium

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Insulin resistance and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Weight-reducing effects of the plasma protein encoded by the obese gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

The role of TNFalpha and TNF receptors in obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Gestational diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Regional adiposity and morbidity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin’s Metabolic and Mitogenic Effects

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

New insights into the role and mechanism of glycogen synthase activation by insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

1 reference

7 January 2021

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Regulation of gene expression by insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Regulation of insulin gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

PPAR gamma and the treatment of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

TNF-alpha and insulin resistance: summary and future prospects

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Searching for type 2 diabetes genes in the post-genome era.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Signaling pathways in insulin action: molecular targets of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. Location! Location! Location!

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

13C/31P NMR studies on the mechanism of insulin resistance in obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Mechanism of free fatty acid-induced insulin resistance in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Thiazolidinediones in the treatment of insulin resistance and type II diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Obesity and diabetes in TNF-alpha receptor- deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Cellular mechanisms of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Obesity and the regulation of energy balance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

The hormone resistin links obesity to diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Syndromes associated with insulin resistance and acanthosis nigricans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Regulation of fatty acid homeostasis in cells: novel role of leptin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Role of the Src homology 2 (SH2) domain and C-terminus tyrosine phosphorylation sites of SH2-containing inositol phosphatase (SHIP) in the regulation of insulin-induced mitogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900239-2

7 January 2021

10.1016/S0092-8674(01)00239-2

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

1550015

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11239409%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1550015

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1550015