GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance. (Q39380536)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22414725%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance (English)

1 reference

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25 January 2020

2

1 reference

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25 January 2020

Amit K Tiwari

3

1 reference

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25 January 2020

Satyakam Singh

4

1 reference

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25 January 2020

author name string

Kamlesh Sodani

1

1 reference

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25 January 2020

Atish Patel

5

1 reference

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25 January 2020

Zhi-Jie Xiao

6

1 reference

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25 January 2020

Jun-Jiang Chen

7

1 reference

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25 January 2020

Yue-Li Sun

8

1 reference

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25 January 2020

Tanaji T Talele

9

1 reference

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25 January 2020

Zhe-Sheng Chen

10

1 reference

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25 January 2020

language of work or name

English

0 references

publication date

7 March 2012

1 reference

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25 January 2020

published in

Biochemical Pharmacology

1 reference

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25 January 2020

volume

83

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25 January 2020

issue

12

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25 January 2020

page(s)

1613-1622

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Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.

25 January 2020

cites work

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Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478

11 September 2017

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Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2

11 September 2017

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Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells

11 September 2017

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Lapatinib: a novel EGFR/HER2 tyrosine kinase inhibitor for cancer.

11 September 2017

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Lessons from the drug discovery of lapatinib, a dual ErbB1/2 tyrosine kinase inhibitor

11 September 2017

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Role of ABCG2/BCRP in biology and medicine

11 September 2017

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Epidermal growth factor receptor (EGFR) signaling in cancer

11 September 2017

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Role of the breast cancer resistance protein (ABCG2) in drug transport

11 September 2017

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Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates

11 September 2017

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Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas

11 September 2017

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Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.

11 September 2017

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The MRP family of drug efflux pumps

11 September 2017

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Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

11 September 2017

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A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

11 September 2017

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Multidrug resistance in cancer: role of ATP-dependent transporters

11 September 2017

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Overview: ABC transporters and human disease

11 September 2017

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The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer

11 September 2017

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The human ATP-binding cassette (ABC) transporter superfamily

11 September 2017

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The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux

11 September 2017

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Expression of the MDR1 gene in human cancers

11 September 2017

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The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone

11 September 2017

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Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters

14 September 2017

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Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression

14 September 2017

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Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance

14 September 2017

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14 September 2017

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Chemopreventive and therapeutic efficacy of orally active tyrosine kinase inhibitors in a transgenic mouse model of gallbladder carcinoma

14 September 2017

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Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.

14 September 2017

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14 September 2017

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Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding

14 September 2017

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Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants.

14 September 2017

1 reference

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Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects

14 September 2017

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15 June 2018

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15 June 2018

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15 June 2018

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15 June 2018

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21 August 2018

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21 August 2018

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Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.

21 August 2018

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Quantitative structure-activity relationship of multidrug resistance reversal agents

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22414725

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22414725

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A phase I and pharmacokinetic study of lapatinib in combination with infusional 5-fluorouracil, leucovorin and irinotecan

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22414725

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BCP.2012.02.028

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22414725%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22414725%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

22414725

1 reference