Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein. (Q34156111)

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18 January 2020

title

Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein (English)

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18 January 2020

7

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18 January 2020

Thomas Stockner

2

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18 January 2020

Sandra Pferschy

4

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18 January 2020

Martin Kraupp

5

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18 January 2020

Michael Freissmuth

6

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18 January 2020

author name string

Zahida Parveen

1

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18 January 2020

Caterina Bentele

3

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18 January 2020

Peter Chiba

8

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18 January 2020

publication date

21 December 2010

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18 January 2020

published in

Molecular Pharmacology

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18 January 2020

volume

79

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18 January 2020

page(s)

443-452

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18 January 2020

issue

3

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The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

18 January 2020

cites work

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12 December 2020

The importance of a nitrogen atom in modulators of multidrug resistance

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12 December 2020

Structure-activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements.

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12 December 2020

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

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12 December 2020

Comparative protein structure modeling of genes and genomes

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12 December 2020

Communication between multiple drug binding sites on P-glycoprotein

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12 December 2020

DNA cloning using in vitro site-specific recombination

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12 December 2020

Can correct protein models be identified?

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12 December 2020

The ATP binding cassette multidrug transporter LmrA and lipid transporter MsbA have overlapping substrate specificities

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12 December 2020

Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein

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12 December 2020

P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach

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12 December 2020

Role of transmembrane domain/transmembrane domain interfaces of P-glycoprotein (ABCB1) in solute transport. Convergent information from photoaffinity labeling, site directed mutagenesis and in silico importance prediction

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12 December 2020

The remarkable transport mechanism of P-glycoprotein: a multidrug transporter

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12 December 2020

Structure of a bacterial multidrug ABC transporter

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12 December 2020

Statistical potential for assessment and prediction of protein structures

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12 December 2020

Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP

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12 December 2020

Fold assessment for comparative protein structure modeling.

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12 December 2020

Flexibility in the ABC transporter MsbA: Alternating access with a twist

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12 December 2020

Mutational analysis of ABC proteins

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12 December 2020

Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.

1 reference

12 December 2020

Multidrug transport by the ABC transporter Sav1866 from Staphylococcus aureus

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12 December 2020

Molecular basis of multidrug transport by ABC transporters

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12 December 2020

Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.

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12 December 2020

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

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12 December 2020

Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesis

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12 December 2020

Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1

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12 December 2020

Membrane transporters in drug development

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12 December 2020

Human P-glycoprotein is active when the two halves are clamped together in the closed conformation

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12 December 2020

The role of a low beta 1-adrenoceptor selectivity of [3H]CGP-12177 for resolving subtype-selectivity of competitive ligands

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12 December 2020

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes

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12 December 2020

Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes

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12 December 2020

The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate

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12 December 2020

Cooperative P-glycoprotein mediated daunorubicin transport into DNA-loaded plasma membrane vesicles

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12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

Benzophenone photophores in biochemistry.

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12 December 2020

Comparative protein modelling by satisfaction of spatial restraints

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12 December 2020

Structural requirements for activity of propafenone-type modulators in P-glycoprotein-mediated multidrug resistance

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12 December 2020

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

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12 December 2020

Identifiers

DOI

10.1124/MOL.110.067611

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18 January 2020

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18 January 2020

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