Increased expression of α-synuclein by SNCA duplication is associated with resistance to toxic stimuli (Q39385017)

11 September 2017

title

Increased expression of α-synuclein by SNCA duplication is associated with resistance to toxic stimuli (English)

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11 September 2017

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1

Han-Joon Kim

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11 September 2017

2

Beom S Jeon

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11 September 2017

Min-Yung Yoon

3

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11 September 2017

Sung-Sup Park

series ordinal

4

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11 September 2017

Kwang-Woo Lee

series ordinal

5

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11 September 2017

publication date

6 March 2012

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Journal of Molecular Neuroscience

11 September 2017

published in

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11 September 2017

volume

47

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11 September 2017

issue

2

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11 September 2017

page(s)

249-255

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alpha-Synuclein gene duplication is present in sporadic Parkinson disease.

11 September 2017

cites work

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Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

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Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.

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Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease

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Alpha-synuclein has structural and functional similarities to small heat shock proteins.

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Beta-synuclein exhibits chaperone activity more efficiently than alpha-synuclein

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Emerging evidence for the neuroprotective role of alpha-synuclein

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SNCA variant associated with Parkinson disease and plasma alpha-synuclein level

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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

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Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication

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Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.

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Expanding the clinical phenotype of SNCA duplication carriers

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Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection.

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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

21 January 2018

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Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain

21 January 2018

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Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

21 January 2018

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12 December 2020

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

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12 December 2020

α-Synuclein Overexpression Protects against Paraquat-Induced Neurodegeneration

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12 December 2020

α-Synuclein multiplication analysis in Italian familial Parkinson disease

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12 December 2020

10.1007/S12031-012-9732-6

Identifiers

DOI

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11 September 2017

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