Topoisomerase I poisoning results in PARP-mediated replication fork reversal (Q39386006)

11 September 2017

title

Topoisomerase I poisoning results in PARP-mediated replication fork reversal (English)

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11 September 2017

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6

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Daniele Fachinetti

5

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Kai J Neelsen

object named as

Kai J Neelsen

4

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Vincenzo Costanzo

object named as

Vincenzo Costanzo

8

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Massimo Lopes

object named as

Massimo Lopes

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author name string

Arnab Ray Chaudhuri

1

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11 September 2017

Yoshitami Hashimoto

2

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11 September 2017

Raquel Herrador

3

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11 September 2017

Andrea Cocito

7

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11 September 2017

publication date

4 March 2012

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Nature Structural & Molecular Biology

11 September 2017

published in

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11 September 2017

volume

19

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11 September 2017

issue

4

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11 September 2017

page(s)

417-423

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Cellular strategies for regulating DNA supercoiling: a single-molecule perspective

11 September 2017

cites work

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Topoisomerase I inhibitors: camptothecins and beyond

21 January 2018

1 reference

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

PARP inhibition: PARP1 and beyond

21 January 2018

1 reference

The DNA damage response and cancer therapy

21 January 2018

1 reference

Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas

21 January 2018

1 reference

PARP inhibitors for cancer therapy.

21 January 2018

1 reference

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

21 January 2018

1 reference

Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements

21 January 2018

1 reference

Replication forks pause at yeast centromeres

21 January 2018

1 reference

Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs

21 January 2018

1 reference

Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation

21 January 2018

1 reference

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

21 January 2018

1 reference

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories.

21 January 2018

1 reference

Next generation topoisomerase I inhibitors: Rationale and biomarker strategies

21 January 2018

1 reference

Human CtIP promotes DNA end resection

21 January 2018

1 reference

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

21 January 2018

1 reference

Electron microscopy methods for studying in vivo DNA replication intermediates

21 January 2018

1 reference

Replication fork reversal and the maintenance of genome stability

21 January 2018

1 reference

Positive torsional strain causes the formation of a four-way junction at replication forks

21 January 2018

1 reference

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

21 January 2018

1 reference

Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

21 January 2018

1 reference

PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.

21 January 2018

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Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

21 January 2018

1 reference

A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks

21 January 2018

1 reference

Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

21 January 2018

1 reference

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

21 January 2018

1 reference

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

21 January 2018

1 reference

Mechanism of replication-coupled DNA interstrand crosslink repair

21 January 2018

1 reference

A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability

21 January 2018

1 reference

Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation

21 January 2018

1 reference

Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

21 January 2018

1 reference

Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

21 January 2018

1 reference

Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase

21 January 2018

1 reference

Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

21 January 2018

1 reference

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

21 January 2018

1 reference

Antitumour drugs impede DNA uncoiling by topoisomerase I

21 January 2018

1 reference

Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma

21 January 2018

1 reference

A model for replication repair in mammalian cells

31 March 2020

1 reference

The Effect of Inhibition of (ADP‐ribose)n Biosynthesis on DNA Repair Assayed by the Nucleoid Technique

31 March 2020

1 reference

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22388737

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.2258

1 reference

release_uwnmrbvhuzde5nl5johonepa7u

11 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/uwnmrbvhuzde5nl5johonepa7u

mapped directly with Wikidata item

24 November 2022

based on heuristic

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