Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin (Q39392568)

11 September 2017

Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin (English)

1 reference

11 September 2017

4

David Crich

1 reference

11 September 2017

Sylvain Aubry

1

1 reference

PubMed ID

22354549

11 September 2017

Geneviève Aubert

series ordinal

2

1 reference

PubMed ID

22354549

11 September 2017

Thierry Cresteil

series ordinal

3

1 reference

11 September 2017

21 February 2012

1 reference

Organic and Biomolecular Chemistry

11 September 2017

1 reference

11 September 2017

10

1 reference

11 September 2017

13

1 reference

11 September 2017

2629-2632

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Acylating drugs: redesigning natural covalent inhibitors

11 September 2017

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Currently available drugs for the treatment of obesity: Sibutramine and orlistat

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Total synthesis and comparative analysis of orlistat, valilactone, and a transposed orlistat derivative: Inhibitors of fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Synthesis of novel beta-lactone inhibitors of fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Click-based synthesis and proteomic profiling of lipstatin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Synthesis of (+/-)- and (-)-vibralactone and vibralactone C

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Double diastereoselective, nucleophile-catalyzed aldol lactonizations (NCAL) leading to beta-lactone fused carbocycles and extensions to beta-lactone fused tetrahydrofurans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Stereodivergency of triazolium and imidazolium-derived NHCs for catalytic, enantioselective cyclopentane synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Nitrone [2+3]-cycloadditions in stereocontrolled synthesis of a potent proteasome inhibitor: (-)-omuralide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Enantioselective total syntheses of omuralide, 7-epi-omuralide, and (+)-lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Beta-lactam congeners of orlistat as inhibitors of fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

The perfect penicillin? Inhibition of a bacterial DD-peptidase by peptidoglycan-mimetic beta-lactams

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

beta-Lactam derivatives as inhibitors of human cytomegalovirus protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Matrix photochemistry, photoelectron spectroscopy, solid-phase structure, and ring strain energy of beta-propiothiolactone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

S(N)2-type nucleophilic opening of beta-thiolactones (thietan-2-ones) as a source of thioacids for coupling reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

The intramolecular asymmetric Pauson-Khand cyclization as a novel and general stereoselective route to benzindene prostacyclins: synthesis of UT-15 (treprostinil).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

An expedient procedure for the oxidative cleavage of olefinic bonds with PhI(OAc)2, NMO, and catalytic OsO4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Enantioselective aldol condensations. 2. Erythro-selective chiral aldol condensations via boron enolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Catalytic Staudinger-Vilarrasa reaction for the direct ligation of carboxylic acids and azides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Synthetic applications of lithiated N-Boc allylic amines as asymmetric homoenolate equivalents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Measurement of pancreatic lipase activity in serum by a kinetic colorimetric assay using a new chromogenic substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB06976H

Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.40.1086

Identifiers

DOI

10.1039/C2OB06976H

1 reference

11 September 2017

1 reference

PubMed ID

22354549