PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis (Q39396087)

11 September 2017

title

PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis (English)

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Hannele Yki-Järvinen

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Julia Perttilä

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Carolina Huaman-Samanez

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2

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Sandrine Caron

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Kimmo Tanhuanpää

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4

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publication date

14 February 2012

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American Journal of Physiology - Endocrinology and Metabolism

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published in

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volume

302

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issue

9

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page(s)

E1063-9

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The natural history of nonalcoholic fatty liver disease: a population-based cohort study

11 September 2017

cites work

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Human fatty liver disease: old questions and new insights

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Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents

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A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

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Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface.

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The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status.

21 January 2018

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A feed-forward loop amplifies nutritional regulation of PNPLA3

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Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene

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A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

21 January 2018

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Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins

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Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity

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Adiponutrin gene is regulated by insulin and glucose in human adipose tissue.

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Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin

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Long-term follow-up of patients with nonalcoholic fatty liver

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Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

21 January 2018

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Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

21 January 2018

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The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

21 January 2018

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Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation

21 January 2018

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A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.

21 January 2018

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Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

21 January 2018

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PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

21 January 2018

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Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes

21 January 2018

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Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage

21 January 2018

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I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease

21 January 2018

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Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.

21 January 2018

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A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

21 January 2018

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10.1152/AJPENDO.00125.2011

21 January 2018

Identifiers

DOI

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11 September 2017

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