Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. (Q39398316)

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22 January 2020

title

Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323726%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

main subject

Caenorhabditis elegans

0 references

1 reference

1

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22 January 2020

Kim A Caldwell

4

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ORCID Public Data File 2021

Guy A Caldwell

series ordinal

5

object named as

Guy A Caldwell

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22 January 2020

author name string

Talene A Yacoubian

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323726%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Sunny R Slone

series ordinal

3

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22 January 2020

language of work or name

English

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publication date

1 February 2012

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22 January 2020

published in

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22323726%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

volume

32

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22 January 2020

issue

6

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22 January 2020

page(s)

2142-2153

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Formation of AP-3 transport intermediates requires Vps41 function

22 January 2020

cites work

1 reference

12 December 2020

Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation

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12 December 2020

Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains

1 reference

12 December 2020

hVPS41 is expressed in multiple isoforms and can associate with vesicles through a RING-H2 finger motif

1 reference

12 December 2020

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

1 reference

12 December 2020

PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans

1 reference

12 December 2020

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

12 December 2020

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

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12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

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12 December 2020

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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12 December 2020

Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

1 reference

12 December 2020

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

1 reference

12 December 2020

Genetic analysis of lysosomal trafficking in Caenorhabditis elegans

1 reference

12 December 2020

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

1 reference

12 December 2020

Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans

1 reference

12 December 2020

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

12 December 2020

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 reference

12 December 2020

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

1 reference

12 December 2020

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

1 reference

12 December 2020

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

1 reference

12 December 2020

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

1 reference

12 December 2020

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

1 reference

12 December 2020

Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase.

1 reference

12 December 2020

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

1 reference

12 December 2020

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

1 reference

12 December 2020

Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites

1 reference

12 December 2020

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

1 reference

12 December 2020

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.

1 reference

12 December 2020

Genome-wide association study reveals genetic risk underlying Parkinson's disease

1 reference

12 December 2020

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

1 reference

12 December 2020

Enhanced neuronal RNAi in C. elegans using SID-1.

1 reference

12 December 2020

Genetic variability at the PARK16 locus

1 reference

12 December 2020

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

1 reference

12 December 2020

Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.

1 reference

12 December 2020

Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease

1 reference

12 December 2020

Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells

1 reference

12 December 2020

Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast

1 reference

12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

12 December 2020

Alpha-synuclein in Lewy bodies

1 reference

12 December 2020

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity

1 reference

12 December 2020

10.1523/JNEUROSCI.2606-11.2012

Identifiers

DOI

1 reference

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22 January 2020

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22 January 2020

PubMed publication ID

22323726

1 reference