VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. (Q39784491)

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scientific article published on 20 October 2009

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English	VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.	scientific article published on 20 October 2009

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scholarly article

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10 February 2020

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease (English)

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10 February 2020

Caenorhabditis elegans

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Parkinson's disease

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inferred from title

David G. Standaert

5

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10 February 2020

Adam J Harrington

2

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10 February 2020

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object named as

Guy A Caldwell

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author name string

Qingmin Ruan

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Kim A Caldwell

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publication date

20 October 2009

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10 February 2020

Neurobiology of Disease

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10 February 2020

330-338

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10 February 2020

Molecular participants in mitochondrial cell death channel formation during neuronal ischemia

1 reference

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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

1 reference

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22 September 2017

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

1 reference

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22 September 2017

Genomic investigation of alpha-synuclein multiplication and parkinsonism

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Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

1 reference

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The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

1 reference

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Disease-modifying pathways in neurodegeneration.

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22 September 2017

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

1 reference

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Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein

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22 September 2017

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 reference

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22 September 2017

Loss of autophagy in the central nervous system causes neurodegeneration in mice

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22 September 2017

Toxin-induced models of Parkinson's disease

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22 September 2017

6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta

1 reference

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22 September 2017

Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10.

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Protein transport from the late Golgi to the vacuole in the yeast Saccharomyces cerevisiae

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22 September 2017

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

1 reference

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Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

1 reference

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Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration

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22 September 2017

Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factor

1 reference

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22 September 2017

Mechanism of toxicity in rotenone models of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818321

22 September 2017

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

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22 September 2017

Caspase-3-mediated cleavage of Rad9 during apoptosis

1 reference

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22 September 2017

Parkinson's disease: mechanisms and models

1 reference

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22 September 2017

The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration

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Neuroprotective and neurorestorative strategies for Parkinson's disease

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22 September 2017

Mitochondrial involvement in the point of no return in neuronal apoptosis

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Mechanisms of caspase activation and inhibition during apoptosis

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22 September 2017

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

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22 September 2017

Complex I and Parkinson's disease

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22 September 2017

Alpha-synuclein and neurodegenerative diseases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818321

22 September 2017

hVPS41 is expressed in multiple isoforms and can associate with vesicles through a RING-H2 finger motif

1 reference

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Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

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Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

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22 September 2017

Formation of AP-3 transport intermediates requires Vps41 function

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Etiology and pathogenesis of Parkinson's disease

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Parkinson's disease. First of two parts

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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Alpha-synuclein in Lewy bodies

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast

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An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

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17 June 2018

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

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Striatal 6-hydroxydopamine induces apoptosis of nigral neurons in the adult rat.

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Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan

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12 December 2020

based on heuristic

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Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19850127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NBD.2009.10.011

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19850127%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19850127%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19850127%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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