Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir (Q39432758)

11 September 2017

Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir (English)

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11 September 2017

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Guanghui Yi

1

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11 September 2017

Jerome Deval

2

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11 September 2017

Baochang Fan

3

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11 September 2017

Hui Cai

4

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11 September 2017

Charlotte Soulard

5

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11 September 2017

C T Ranjith-Kumar

6

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11 September 2017

David B Smith

7

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11 September 2017

Lawrence Blatt

8

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11 September 2017

Leonid Beigelman

9

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11 September 2017

C Cheng Kao

10

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11 September 2017

language of work or name

English

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publication date

5 December 2011

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Antimicrobial Agents and Chemotherapy

11 September 2017

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11 September 2017

56

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2

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830-837

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describes a project that uses

11 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3264230/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Telaprevir for previously untreated chronic hepatitis C virus infection

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Boceprevir for previously treated chronic HCV genotype 1 infection

11 September 2017

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Filibuvir, a non-nucleoside NS5B polymerase inhibitor for the potential oral treatment of chronic HCV infection

11 September 2017

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Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions.

11 September 2017

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Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection

11 September 2017

1 reference

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Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

11 September 2017

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Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor

11 September 2017

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A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

11 September 2017

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

11 September 2017

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Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor

11 September 2017

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Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition

11 September 2017

1 reference

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Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

11 September 2017

1 reference

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Challenges and successes in developing new therapies for hepatitis C.

11 September 2017

1 reference

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Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

11 September 2017

1 reference

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Initiation of viral RNA-dependent RNA polymerization

11 September 2017

1 reference

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Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

11 September 2017

1 reference

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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264230

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264230

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

11 September 2017

1 reference

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Hepatitis C virus infection

11 September 2017

1 reference

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Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase

11 September 2017

1 reference

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De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264230

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264230

Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264230

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

11 September 2017

1 reference

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HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus

11 September 2017

1 reference

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The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture

14 September 2017

1 reference

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Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase

14 September 2017

1 reference

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Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.

14 September 2017

1 reference

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Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate

14 September 2017

1 reference

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Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

14 September 2017

1 reference

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Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

14 September 2017

1 reference

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Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

14 September 2017

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Antiviral activity of the hepatitis C virus polymerase inhibitor filibuvir in genotype 1-infected patients

15 June 2018

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HCV RNA-dependent RNA polymerase replicates in vitro the 3' terminal region of the minus-strand viral RNA more efficiently than the 3' terminal region of the plus RNA.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264230

De novo initiation of RNA synthesis by a recombinant flaviviridae RNA-dependent RNA polymerase

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264230

21 August 2018

Identifiers

DOI

10.1128/AAC.05438-11

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11 September 2017

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11 September 2017

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