A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse (Q39435733)

11 September 2017

A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse (English)

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11 September 2017

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14

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11 September 2017

Rachel Evans

2

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Leo Carlin

Leo M Carlin

1

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Simon Ameer-beg

Simon Ameer-Beg

15

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Borivoj Vojnovic

Borivoj Vojnovic

Peter Joseph Jacques Parker

12

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Peter J Parker

16

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Tony Ng

Tony Ng

18

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Klaus Suhling

13

Klaus Suhling

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11 September 2017

Hanna Milewicz

3

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11 September 2017

Luis Fernandes

4

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11 September 2017

Daniel R Matthews

5

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11 September 2017

Michela Perani

6

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11 September 2017

James Levitt

7

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11 September 2017

Melanie D Keppler

8

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11 September 2017

James Monypenny

9

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11 September 2017

Ton Coolen

10

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11 September 2017

Paul R Barber

11

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11 September 2017

N Shaun B Thomas

17

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11 September 2017

29 November 2011

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11 September 2017

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11 September 2017

4

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11 September 2017

201

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11 September 2017

ra81

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Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

11 September 2017

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Activation of endogenous Cdc42 visualized in living cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Spatiotemporal dynamics of RhoA activity in migrating cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Visualisation of signalling in immune cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Time-lapse FRET microscopy using fluorescence anisotropy

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

satFRET: estimation of Förster resonance energy transfer by acceptor saturation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Monitoring spatio-temporal regulation of Ras and Rho GTPase with GFP-based FRET probes.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Oscillatory ROP GTPase activation leads the oscillatory polarized growth of pollen tubes.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Biology of natural killer cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

The human natural killer cell immune synapse

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

What is the importance of the immunological synapse?

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Natural killer cell signal integration balances synapse symmetry and migration

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Chemokine-induced monocyte transmigration requires cdc42-mediated cytoskeletal changes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Rho GTPases control polarity, protrusion, and adhesion during cell movement

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Activity of Rho-family GTPases during cell division as visualized with FRET-based probes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Imaging proteins in vivo using fluorescence lifetime microscopy

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

The potential of optical proteomic technologies to individualize prognosis and guide rational treatment for cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

How Förster resonance energy transfer imaging improves the understanding of protein interaction networks in cancer biology

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Human Protein Reference Database--2009 update

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

The Pfam protein families database

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Vav1 Controls DAP10-Mediated Natural Cytotoxicity by Regulating Actin and Microtubule Dynamics

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

The mature activating natural killer cell immunologic synapse is formed in distinct stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

The actin cytoskeleton controls the efficiency of killer Ig-like receptor accumulation at inhibitory NK cell immune synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

A gene atlas of the mouse and human protein-encoding transcriptomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

p95-APP1 links membrane transport to Rac-mediated reorganization of actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Regulation of lymphocyte-mediated killing by GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Oscillations in NF-kappaB signaling control the dynamics of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Opposing Effects of PKCθ and WASp on Symmetry Breaking and Relocation of the Immunological Synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

Multiphoton time-domain fluorescence lifetime imaging microscopy: practical application to protein-protein interactions using global analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001729

10.1126/SCISIGNAL.2001729

21 January 2018

Identifiers

DOI

1 reference

11 September 2017

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