Inhibition of proteasome deubiquitinating activity as a new cancer therapy (Q39447379)

12 September 2017

Inhibition of proteasome deubiquitinating activity as a new cancer therapy (English)

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12 September 2017

Michelandrea De Cesare

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12 September 2017

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12 September 2017

Behnam Sadeghi

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Pádraig D'arcy

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Pádraig D'Arcy

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Moustapha Hassan

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Moustapha Hassan

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Rolf Larsson

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object named as

Rolf Larsson

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12 September 2017

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Stig Linder

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12 September 2017

Slavica Brnjic

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12 September 2017

Maria Hägg Olofsson

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12 September 2017

Mårten Fryknäs

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12 September 2017

Kristina Lindsten

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12 September 2017

language of work or name

English

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publication date

6 November 2011

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

1636-1640

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https://scigraph.springernature.com/pub.10.1038/nm.2536

12 September 2017

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cites work

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

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12 December 2020

Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.

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12 December 2020

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids

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12 December 2020

Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome

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12 December 2020

Development of the proteasome inhibitor Velcade (Bortezomib).

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12 December 2020

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

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12 December 2020

Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome.

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12 December 2020

Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes

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12 December 2020

The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry".

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12 December 2020

Pharmacophore model for novel inhibitors of ubiquitin isopeptidases that induce p53-independent cell death

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12 December 2020

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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12 December 2020

Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

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12 December 2020

Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent

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12 December 2020

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis

1 reference

12 December 2020

An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome

1 reference

12 December 2020

The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies

1 reference

12 December 2020

Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice

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12 December 2020

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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12 December 2020

In vivo ubiquitination and proteasome-mediated degradation of p53(1)

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12 December 2020

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome

1 reference

12 December 2020

Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker

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12 December 2020

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

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12 December 2020

A cryptic protease couples deubiquitination and degradation by the proteasome

1 reference

12 December 2020

Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response

1 reference

12 December 2020

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

1 reference

12 December 2020

The multicatalytic and 26 S proteases

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12 December 2020

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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12 December 2020

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

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12 December 2020

A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues

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12 December 2020

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

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12 December 2020

Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types

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12 December 2020

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

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12 December 2020

Identifiers

DOI

10.1038/NM.2536

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12 September 2017

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