New prodrugs of the antiprotozoal drug pentamidine (Q39460980)

12 September 2017

title

New prodrugs of the antiprotozoal drug pentamidine (English)

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12 September 2017

7

Walter Raasch

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author name string

Joscha Kotthaus

1

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12 September 2017

Jürke Kotthaus

2

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12 September 2017

Dennis Schade

3

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12 September 2017

Ulrike Schwering

4

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12 September 2017

Helen Hungeling

5

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12 September 2017

Helge Müller-Fielitz

6

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12 September 2017

Walter Raasch

7

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12 September 2017

Bernd Clement

8

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12 September 2017

publication date

7 October 2011

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12 September 2017

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12 September 2017

volume

6

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12 September 2017

issue

12

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12 September 2017

page(s)

2233-2242

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2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents

12 September 2017

cites work

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https://api.crossref.org/works/10.1002%2FCMDC.201100422

Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia

21 January 2018

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Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan

21 January 2018

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New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289

21 January 2018

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Reduction of N-hydroxylated compounds: amidoximes (N-hydroxyamidines) as pro-drugs of amidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

Diacetyldiamidoximeester of pentamidine, a prodrug for treatment of protozoal diseases: synthesis, in vitro and in vivo biotransformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

N,N'-dihydroxyamidines: a new prodrug principle to improve the oral bioavailability of amidines

21 January 2018

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Impact of OATP transporters on pharmacokinetics

21 January 2018

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Blood-brain barrier transporters and response to CNS-active drugs

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Plasma protein binding displacement interactions--why are they still regarded as clinically important?

21 January 2018

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Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine

21 January 2018

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Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

Antileishmanial activities of several classes of aromatic dications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

Trypanocidal activity of conformationally restricted pentamidine congeners

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201100422

Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

Reduction of amidoxime derivatives to pentamidine in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

7 January 2021

Enzymatic reduction of benzamidoxime to benzamidine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

7 January 2021

Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

7 January 2021

Synthesis and biological evaluation of L-valine-amidoximeesters as double prodrugs of amidines

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100422

7 January 2021

Characterization of a peptide alpha-amidation activity in human plasma and tissues

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https://api.crossref.org/works/10.1002%2FCMDC.201100422

7 January 2021

Identifiers

DOI

10.1002/CMDC.201100422

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12 September 2017

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