AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications. (Q39463725)

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14 February 2020

title

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications (English)

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1 reference

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lymphoblastic leukemia

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T-cell acute lymphoblastic leukemia

inferred from title

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7

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Andrea Pession

13

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João T. Barata

14

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James A. McCubrey

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author name string

C Grimaldi

1

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F Chiarini

2

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G Tabellini

3

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F Ricci

4

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P L Tazzari

5

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M Battistelli

6

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R Bortul

8

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F Melchionda

9

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I Iacobucci

10

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P Pagliaro

11

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G Martinelli

12

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A M Martelli

16

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publication date

4 October 2011

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volume

26

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page(s)

91-100

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issue

1

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https://scigraph.springernature.com/pub.10.1038/leu.2011.269

14 February 2020

exact match

0 references

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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

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Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling

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Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.

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TSC2 mediates cellular energy response to control cell growth and survival

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

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Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms

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Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia.

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Identifiers

DOI

10.1038/LEU.2011.269

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968881%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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