Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation (Q39493410)

12 September 2017

title

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation (English)

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12 September 2017

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12 June 2020

Michael R Bowman

3

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12 June 2020

Cedric Hubeau

5

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12 June 2020

Brian G Monks

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12 June 2020

Stephen Wang

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12 June 2020

Aiping Jiao

13

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12 June 2020

author name string

Michael J Primiano

1

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12 June 2020

Andrea G Bree

4

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12 June 2020

Paul D Bonin

6

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12 June 2020

Matthew Mangan

7

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12 June 2020

Ken Dower

8

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12 June 2020

Leah Cushing

10

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12 June 2020

Julia Guzova

12

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12 June 2020

Lih-Ling Lin

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12 June 2020

Eicke Latz

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12 June 2020

David Hepworth

16

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12 June 2020

J Perry Hall

17

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12 June 2020

language of work or name

English

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publication date

12 August 2016

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12 September 2017

published in

Journal of Immunology

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12 June 2020

volume

197

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12 June 2020

issue

6

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12 June 2020

page(s)

2421-2433

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12 June 2020

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

The inflammasome: a danger sensing complex triggering innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Activation and regulation of the inflammasomes

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Inflammasomes: mechanism of action, role in disease, and therapeutics

21 January 2018

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Regulation of interleukin 1α secretion by inflammasomes

21 January 2018

1 reference

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NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.

21 January 2018

1 reference

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Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

21 January 2018

1 reference

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Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis.

21 January 2018

1 reference

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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

21 January 2018

1 reference

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

21 January 2018

1 reference

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Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

21 January 2018

1 reference

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New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease

21 January 2018

1 reference

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Is the inflammasome a potential therapeutic target in renal disease?

21 January 2018

1 reference

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How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Cryopyrin-associated periodic syndromes: diagnosis and management

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Treating inflammation by blocking interleukin-1 in humans

21 January 2018

1 reference

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Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing

21 January 2018

1 reference

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Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance

21 January 2018

1 reference

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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Analysis of Pfizer compounds in EPA's ToxCast chemicals-assay space

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

21 January 2018

Cytokines in psoriasis

1 reference

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IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression

21 January 2018

1 reference

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Psoriasis: what we have learned from mouse models

21 January 2018

1 reference

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TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis

21 January 2018

1 reference

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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria

21 January 2018

1 reference

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IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome.

21 January 2018

1 reference

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Aldara activates TLR7-independent immune defence

21 January 2018

1 reference

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Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.

21 January 2018

1 reference

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An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma

21 January 2018

1 reference

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A potential role for P2X7R in allergic airway inflammation in mice and humans

21 January 2018

1 reference

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Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1600035

Analysis of NLRP3 in the development of allergic airway disease in mice

21 January 2018

1 reference

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Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.4049/JIMMUNOL.1600035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27521339%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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