Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant (Q39500562)

12 September 2017

title

Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant (English)

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12 September 2017

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9

Ben A Oostra

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12 September 2017

Andreea S Pop

1

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12 September 2017

Josien Levenga

2

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12 September 2017

Celine E F de Esch

3

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12 September 2017

Ronald A M Buijsen

4

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12 September 2017

Ingeborg M Nieuwenhuizen

5

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12 September 2017

Tracy Li

6

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12 September 2017

Aaron Isaacs

7

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12 September 2017

Fabrizio Gasparini

8

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12 September 2017

Rob Willemsen

10

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12 September 2017

publication date

21 December 2012

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12 September 2017

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12 September 2017

volume

231

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12 September 2017

issue

6

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12 September 2017

page(s)

1227-1235

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Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses

12 September 2017

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The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation

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Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome.

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Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines.

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Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

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Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination.

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Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.

21 January 2018

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AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

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Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome

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21 January 2018

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21 January 2018

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Which comes first in fragile X syndrome, dendritic spine dysgenesis or defects in circuit plasticity?

21 January 2018

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Dendritic Spine "Dysgenesis" and Mental Retardation

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21 January 2018

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Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome.

21 January 2018

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Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

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Development of long-term dendritic spine stability in diverse regions of cerebral cortex

21 January 2018

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Abnormal development of dendritic spines in FMR1 knock-out mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23254376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00213-012-2947-Y

1 reference

release_rrbwogokpvgx5mjbgufr3zdyt4

12 September 2017

Fatcat ID

0 references

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