Long-term exposure of gastrointestinal stromal tumor cells to sunitinib induces epigenetic silencing of the PTEN gene (Q39568926)

13 September 2017

Long-term exposure of gastrointestinal stromal tumor cells to sunitinib induces epigenetic silencing of the PTEN gene (English)

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gastrointestinal stromal tumor

13 September 2017

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Jing Yang

1

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13 September 2017

Takayuki Ikezoe

2

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13 September 2017

Chie Nishioka

3

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13 September 2017

Yuka Takezaki

4

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13 September 2017

Kazuhiro Hanazaki

5

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13 September 2017

Takahiro Taguchi

6

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13 September 2017

Akihito Yokoyama

7

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13 September 2017

language of work or name

English

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publication date

18 June 2011

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International Journal of Cancer

13 September 2017

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13 September 2017

130

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13 September 2017

4

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13 September 2017

959-966

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Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era--a population-based study in western Sweden

13 September 2017

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Gastrointestinal stromal tumors in Iceland, 1990-2003: the icelandic GIST study, a population-based incidence and pathologic risk stratification study.

21 January 2018

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Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival.

21 January 2018

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Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

21 January 2018

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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

21 January 2018

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KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size

21 January 2018

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

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Molecular pathobiology of gastrointestinal stromal sarcomas.

21 January 2018

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Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT.

21 January 2018

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Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033.

21 January 2018

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Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation

21 January 2018

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Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene.

21 January 2018

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Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate

21 January 2018

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Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

21 January 2018

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Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial

21 January 2018

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Lost in translation: dysregulation of cap-dependent translation and cancer

21 January 2018

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Upstream and downstream of mTOR

21 January 2018

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PTEN promoter methylation in sporadic thyroid carcinomas.

21 January 2018

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

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Conventional and molecular cytogenetic characterization of a new human cell line, GIST-T1, established from gastrointestinal stromal tumor

21 January 2018

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Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling

21 January 2018

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HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling

21 January 2018

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HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24.

21 January 2018

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KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway

21 January 2018

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Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells

21 January 2018

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Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA).

21 January 2018

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The drug-resistance to gefitinib in PTEN low expression cancer cells is reversed by irradiation in vitro

21 January 2018

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Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors

21 January 2018

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Multitargeted tyrosine kinase inhibitor stimulates expression of IL-6 and activates JAK2/STAT5 signaling in acute myelogenous leukemia cells.

21 January 2018

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Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene

21 January 2018

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PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.26095

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13 September 2017

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