Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative (Q39579072)

13 September 2017

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title

Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative (English)

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13 September 2017

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Slater EE

1

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PubMed ID

3076125

13 September 2017

MacDonald JS

series ordinal

2

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13 September 2017

1 January 1988

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13 September 2017

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13 September 2017

36 Suppl 3

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13 September 2017

72-82

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ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

13 September 2017

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12 December 2020

Detection of familial hypercholesterolemia by assaying functional low-density-lipoprotein receptors on lymphocytes

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12 December 2020

Regulation of HMG-CoA reductase

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12 December 2020

Lipid metabolism and atherosclerosis

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12 December 2020

Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers

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12 December 2020

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: a new class of cholesterol-lowering agents

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12 December 2020

Hydroxymethylglutaryl-coenzyme A reductase exhibits graded distribution in normal and mevinolin-treated ileum

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12 December 2020

beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver

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12 December 2020

A receptor-mediated pathway for cholesterol homeostasis

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12 December 2020

Brain and optic system pathology in hypocholesterolemic dogs treated with a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

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12 December 2020

Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes

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12 December 2020

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

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12 December 2020

Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol

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12 December 2020

Ultrastructural analysis of crystalloid endoplasmic reticulum in UT-1 cells and its disappearance in response to cholesterol

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12 December 2020

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin

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12 December 2020

The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering

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12 December 2020

The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease

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12 December 2020

Regulation of hepatic receptor-dependent degradation of LDL by mevinolin in rabbits with hypercholesterolemia induced by a wheat starch-casein diet

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12 December 2020

Structure elucidation of the bioactive metabolites of ML-236B (mevastatin) isolated from dog urine

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12 December 2020

Efficacy and long-term adverse effect pattern of lovastatin

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12 December 2020

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

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12 December 2020

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor

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12 December 2020

10.2165/00003495-198800363-00016

Identifiers

DOI

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PubMed ID

3076125

1 reference

PubMed ID

3076125