The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α. (Q39579573)

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24 January 2020

title

The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α (English)

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Carla Cicchini

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Alice Conigliaro

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Carmine Mancone

6

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Laura Amicone

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Marco Tripodi

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author name string

Laura Santangelo

1

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24 January 2020

Beatrice Conti

5

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24 January 2020

Jessica A Bonzo

7

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Frank J Gonzalez

8

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Tonino Alonzi

9

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language of work or name

English

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publication date

1 June 2011

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volume

53

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issue

6

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page(s)

2063-2074

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Epithelial-mesenchymal transitions in development and disease

24 January 2020

cites work

1 reference

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

21 January 2018

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The Snail genes as inducers of cell movement and survival: implications in development and cancer.

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Epithelial-to-mesenchymal transitions in the liver

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TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling.

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Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro

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Evidence for epithelial-mesenchymal transitions in adult liver cells.

21 January 2018

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Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

21 January 2018

1 reference

Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis

21 January 2018

1 reference

Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors

21 January 2018

1 reference

Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats

21 January 2018

1 reference

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

21 January 2018

1 reference

Convergence of Wnt signaling on the HNF4alpha-driven transcription in controlling liver zonation

21 January 2018

1 reference

Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells

21 January 2018

1 reference

Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3' end splicing

21 January 2018

1 reference

Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

21 January 2018

1 reference

The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

21 January 2018

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Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes

21 January 2018

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A transcriptional hierarchy involved in mammalian cell-type specification

21 January 2018

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Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription

21 January 2018

1 reference

Control of pancreas and liver gene expression by HNF transcription factors

21 January 2018

1 reference

Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.

21 January 2018

1 reference

Transcription factor HNF and hepatocyte differentiation

21 January 2018

1 reference

Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization

21 January 2018

1 reference

Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays

21 January 2018

1 reference

A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors

21 January 2018

1 reference

Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis

21 January 2018

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The SLUG zinc-finger protein represses E-cadherin in breast cancer

21 January 2018

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12 December 2020

Mechanisms of mutual functional interactions between HNF-4alpha and HNF-1alpha revealed by mutations that cause maturity onset diabetes of the young

1 reference

12 December 2020

Snail controls differentiation of hepatocytes by repressing HNF4α expression

1 reference

12 December 2020

Hepatic HNF4α deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes

1 reference

12 December 2020

Identifiers

DOI

10.1002/HEP.24280

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PubMed publication ID

21384409

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