α4 is highly expressed in carcinogen-transformed human cells and primary human cancers (Q39588362)

13 September 2017

α4 is highly expressed in carcinogen-transformed human cells and primary human cancers (English)

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13 September 2017

L-P Chen

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Y-D Lai

2

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D-C Li

3

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X-N Zhu

4

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13 September 2017

P Yang

5

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W-X Li

6

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13 September 2017

W Zhu

7

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13 September 2017

J Zhao

8

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X-D Li

9

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13 September 2017

Y-M Xiao

10

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13 September 2017

Y Zhang

11

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13 September 2017

X-M Xing

12

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13 September 2017

Q Wang

13

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B Zhang

14

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Y-C Lin

15

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13 September 2017

J-L Zeng

16

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13 September 2017

S-X Zhang

17

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13 September 2017

C-X Liu

18

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13 September 2017

Z-F Li

19

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13 September 2017

X-W Zeng

20

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13 September 2017

Z-N Lin

21

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Z-X Zhuang

22

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W Chen

23

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13 September 2017

language of work or name

English

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publication date

21 February 2011

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30

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26

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2943-2953

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https://scigraph.springernature.com/pub.10.1038/onc.2011.20

13 September 2017

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Alpha 4 associates with protein phosphatases 2A, 4, and 6

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Identification of specific PP2A complexes involved in human cell transformation

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MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth

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The protein phosphatase 2A subunit Bgamma gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization

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Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

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Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells

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The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration

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Alpha4 is an essential regulator of PP2A phosphatase activity

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The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis

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Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

21 January 2018

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Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination

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alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein

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PP2A: unveiling a reluctant tumor suppressor

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B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

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Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway

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Development of human cell models for assessing the carcinogenic potential of chemicals

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miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia

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Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.

21 January 2018

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The tumor suppressor PP2A Abeta regulates the RalA GTPase

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A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A

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Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42.

21 January 2018

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MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation

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Protein phosphatase 2A: a panoply of enzymes.

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Multiple pathways regulated by the tumor suppressor PP2A in transformation

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TOR signaling in growth and metabolism

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The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation

21 January 2018

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Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy

21 January 2018

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DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution

21 January 2018

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Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity

21 January 2018

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Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes

31 March 2020

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Protein phosphatase 2A: who shall regulate the regulator?

31 March 2020

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Protein phosphatase PP4 is overexpressed in human breast and lung tumors

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2011.20

1 reference

13 September 2017

1 reference