Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy. (Q39593069)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21317459%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy (English)

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22 January 2020

6

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22 January 2020

author name string

Bhavya Rao

1

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22 January 2020

Ingeborg M M van Leeuwen

2

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22 January 2020

Maureen Higgins

3

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22 January 2020

Johanna Campbel

4

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22 January 2020

Alastair M Thompson

5

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22 January 2020

Sonia Lain

7

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22 January 2020

language of work or name

English

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publication date

1 November 2010

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22 January 2020

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22 January 2020

volume

1

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22 January 2020

page(s)

639-650

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22 January 2020

issue

7

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Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53.

22 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

14 September 2017

1 reference

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p53 in health and disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Basis of actinomycin action. II. Effect of actinomycin on the nucleoside triphosphate-inorganic pyrophosphate exchange

14 September 2017

1 reference

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Regulation of HDM2 activity by the ribosomal protein L11

14 September 2017

1 reference

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Improving cancer therapy by non-genotoxic activation of p53.

14 September 2017

1 reference

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Cyclotherapy: protection of normal cells and unshielding of cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Live or let die: the cell's response to p53

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Exploiting cancer cell cycling for selective protection of normal cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

The MDM2 gene amplification database

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

p53 mutations in human cancers

14 September 2017

1 reference

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Cancer. p53, guardian of the genome

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

The interaction of actinomycin with DNA.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248124

Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs

25 September 2017

1 reference

12 December 2020

Potential of actinomycin in cancer control

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12 December 2020

Clinical studies on actinomycin D with special reference to Wilms' tumor in children

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12 December 2020

ACTINOMYCIN INHIBITION OF RNA SYNTHESIS DIRECTED BY DNA

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12 December 2020

Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors

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12 December 2020

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21317459%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

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