Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs (Q74737230)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12214265%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12214265%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1

Mikhail V Blagosklonny

1 reference

12 November 2019

language of work or name

English

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publication date

1 September 2002

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12214265%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12214265%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

volume

21

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12 November 2019

page(s)

6249-6254

1 reference

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12 November 2019

issue

41

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205793

12 November 2019

exact match

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Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

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Drug-resistance enables selective killing of resistant leukemia cells: exploiting of drug resistance instead of reversal.

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Unwinding the loop of Bcl-2 phosphorylation

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Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs

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Paclitaxel-induced FasL-independent apoptosis and slow (non-apoptotic) cell death.

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

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7 January 2021

Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity

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7 January 2021

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway

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Microtubules and actin filaments: dynamic targets for cancer chemotherapy

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P53, cell cycle control and apoptosis: implications for cancer

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Mechanism by which caffeine potentiates lethality of nitrogen mustard

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The G(2) checkpoint is maintained by redundant pathways

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Surfing the p53 network

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Cell-cycle control and its watchman.

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UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.

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7 January 2021