Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling (Q39600616)

13 September 2017

Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling (English)

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13 September 2017

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C Garofalo

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Piero Picci

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P Picci

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Annalisa Astolfi

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A Astolfi

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13 September 2017

M C Manara

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G Nicoletti

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M T Marino

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G Pandini

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J A López-Guerrero

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K-L Schaefer

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A Belfiore

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K Scotlandi

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language of work or name

English

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publication date

31 January 2011

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13 September 2017

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30

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2730-2740

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24

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https://scigraph.springernature.com/pub.10.1038/onc.2010.640

13 September 2017

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Redundancy of autocrine loops in human osteosarcoma cells.

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Silencing of the insulin receptor isoform A favors formation of type 1 insulin-like growth factor receptor (IGF-IR) homodimers and enhances ligand-induced IGF-IR activation and viability of human colon carcinoma cells.

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Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer

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Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody

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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.

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The type 1 insulin-like growth factor receptor pathway

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IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.

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Insulin receptor (IR) pathway hyperactivity in IGF-IR null cells and suppression of downstream growth signaling using the dual IGF-IR/IR inhibitor, BMS-754807.

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A monoclonal anti-peptide antibody reacting with the insulin receptor β-subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptors

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Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream

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Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition

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The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors

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Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

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Molecular diagnosis of Ewing sarcoma family of tumors: a comparative analysis of 560 cases with FISH and RT-PCR.

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NVP-BEZ235 as a new therapeutic option for sarcomas.

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Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression

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EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

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Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer.

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In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A.

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Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

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Targeting insulin-like growth factor 1 receptor in sarcomas

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The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts

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Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

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Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: effect of the dual-receptor inhibitor BMS-536924 in vitro

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Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin.

21 January 2018

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Analysis of insulin signalling by RNAi-based gene silencing

21 January 2018

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The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric Transcripts

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.640

21 January 2018

Identifiers

DOI

10.1038/ONC.2010.640

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Dimensions Publication ID

13 September 2017

1007760714

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Fatcat ID

release_drk4j6b2hzc73e3jecynue5qpm

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1 reference