Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277 (Q39615561)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034820%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

title

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277 (English)

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9 November 2019

2

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9 November 2019

author name string

Jiri Buzek

1

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9 November 2019

Sari Kurki

3

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9 November 2019

Karita Peltonen

4

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9 November 2019

Marikki Laiho

5

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9 November 2019

language of work or name

English

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publication date

1 June 2002

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9 November 2019

number of pages

9

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inferred from page(s)

published in

Nucleic Acids Research

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9 November 2019

volume

30

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9 November 2019

page(s)

2340-2348

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9 November 2019

issue

11

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

9 November 2019

cites work

1 reference

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UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts

14 September 2017

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Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein

14 September 2017

1 reference

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p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction

14 September 2017

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Kinetics of p53 binding to promoter sites in vivo

14 September 2017

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14 September 2017

Surfing the p53 network

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

14 September 2017

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

14 September 2017

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

14 September 2017

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Redox signalling and transition metals in the control of the p53 pathway

14 September 2017

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One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element

14 September 2017

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Increased apoptosis induction by 121F mutant p53

14 September 2017

1 reference

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

14 September 2017

1 reference

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Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding

14 September 2017

1 reference

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IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

14 September 2017

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Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

14 September 2017

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A model for p53-induced apoptosis

14 September 2017

1 reference

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Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

14 September 2017

1 reference

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WAF1, a potential mediator of p53 tumor suppression

14 September 2017

1 reference

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Role of cysteine residues in regulation of p53 function

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Definition of a consensus binding site for p53

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Discrimination of DNA binding sites by mutant p53 proteins

14 September 2017

1 reference

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Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

14 September 2017

1 reference

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Mutation of conserved domain II alters the sequence specificity of DNA binding by the p53 protein.

25 September 2017

1 reference

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p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Drosophila p53 binds a damage response element at the reaper locus

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast Schizosaccharomyces pombe.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Thioredoxin-dependent redox regulation of p53-mediated p21 activation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Increased salt concentration reversibly destabilizes p53 quaternary structure and sequence-specific DNA binding.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Latent and active p53 are identical in conformation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117181

Mutations at position 277 modify the DNA-binding specificity of human p53 in vitro

2 December 2018

1 reference

12 December 2020

p53 Protein exhibits 3'-to-5' exonuclease activity

1 reference

12 December 2020

Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest

1 reference

12 December 2020

DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53

1 reference

12 December 2020

The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter

1 reference

12 December 2020

Effect of p53 protein redox states on binding to supercoiled and linear DNA

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/30.11.2340

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034820%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034820%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference