The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter (Q73694178)

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6 November 2019

title

The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter (English)

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6 November 2019

author name string

Thornborrow EC

series ordinal

1

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6 November 2019

Manfredi JJ

series ordinal

2

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6 November 2019

language of work or name

English

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publication date

13 February 2001

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Journal of Biological Chemistry

6 November 2019

published in

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6 November 2019

volume

276

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6 November 2019

issue

19

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6 November 2019

page(s)

15598-15608

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Bax directly induces release of cytochrome c from isolated mitochondria

6 November 2019

cites work

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Release of cytochrome c and decrease of cytochrome c oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-xL

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The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition

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Cytochrome c in the apoptotic and antioxidant cascades

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

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21 January 2018

p53: puzzle and paradigm

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p53, the cellular gatekeeper for growth and division

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Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

21 January 2018

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Identification of p53 as a sequence-specific DNA-binding protein

21 January 2018

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Presence of a potent transcription activating sequence in the p53 protein

21 January 2018

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A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

21 January 2018

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The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

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p53 domains: identification and characterization of two autonomous DNA-binding regions.

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Sequence-specific transcriptional activation is essential for growth suppression by p53.

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Definition of a consensus binding site for p53

21 January 2018

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A transcriptionally active DNA-binding site for human p53 protein complexes

21 January 2018

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Induction of the growth inhibitor IGF-binding protein 3 by p53

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

21 January 2018

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The mdm-2 gene is induced in response to UV light in a p53-dependent manner

21 January 2018

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Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice

21 January 2018

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Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

21 January 2018

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Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast

21 January 2018

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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

21 January 2018

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Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

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Bax suppresses tumorigenesis and stimulates apoptosis in vivo

21 January 2018

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Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

21 January 2018

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Suppression of human colorectal carcinoma cell growth by wild-type p53

21 January 2018

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Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif

21 January 2018

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One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element

21 January 2018

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MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

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21 January 2018

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p53 and Sp1 interact and cooperate in the tumor necrosis factor-induced transcriptional activation of the HIV-1 long terminal repeat

21 January 2018

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p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.

21 January 2018

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Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1.

21 January 2018

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Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene

21 January 2018

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Interaction between transcription factors Sp1 and YY1.

21 January 2018

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A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

21 January 2018

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21 January 2018

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Identification and characterization of a p53 homologue in Drosophila melanogaster

21 January 2018

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Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.

21 January 2018

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High Sp1/Sp3 ratios in epithelial cells during epithelial differentiation and cellular transformation correlate with the activation of the HPV-16 promoter.

21 January 2018

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Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor

21 January 2018

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21 January 2018

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bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

21 January 2018

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Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

21 January 2018

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Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis

21 January 2018

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bax, but not bcl-2, influences the prognosis of human pancreatic cancer

21 January 2018

1 reference

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Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases

21 January 2018

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Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

21 January 2018

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Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice

21 January 2018

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Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis

21 January 2018

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Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis

21 January 2018

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The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21(BAX) expression

21 January 2018

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Impaired BAX protein expression in breast cancer: mutational analysis of the BAX and the p53 gene

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M011643200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11278953%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference