Reconstitution of human MCF-7 breast cancer cells with caspase-3 does not sensitize them to action of CDK inhibitors (Q39631323)

13 September 2017

title

Reconstitution of human MCF-7 breast cancer cells with caspase-3 does not sensitize them to action of CDK inhibitors (English)

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13 September 2017

author

Józefa Wesierska-Gadek

1

object named as

Józefa Węsierska-Gądek

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13 September 2017

Stefan Hackl

2

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13 September 2017

Nora Zulehner

3

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13 September 2017

Margarita Maurer

4

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13 September 2017

Oxana Komina

5

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13 September 2017

publication date

1 January 2011

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Journal of Cellular Biochemistry

13 September 2017

published in

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13 September 2017

volume

112

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13 September 2017

issue

1

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13 September 2017

page(s)

273-288

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A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

13 September 2017

cites work

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Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

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Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells

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Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance

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Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis

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Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

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Cell cycle kinases as therapeutic targets for cancer

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Activation of p53 by roscovitine-mediated suppression of MDM2 expression

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Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

21 January 2018

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Roscovitine differentially affects asynchronously growing and synchronized human MCF-7 breast cancer cells

21 January 2018

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Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

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Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine

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J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

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CDK inhibitors: from the bench to clinical trials.

21 January 2018

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R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer

21 January 2018

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CDK inhibitors as potential breast cancer therapeutics: new evidence for enhanced efficacy in ER+ disease

21 January 2018

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RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells.

21 January 2018

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Inhibition of cyclin-dependent kinases by purine analogues

21 January 2018

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A Detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis

21 January 2018

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Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia?

21 January 2018

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Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein

21 January 2018

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Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest

21 January 2018

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A new multiplex assay allowing simultaneous detection of the inhibition of cell proliferation and induction of cell death.

21 January 2018

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Phenol red reduces ROSC mediated cell cycle arrest and apoptosis in human MCF-7 cells

21 January 2018

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Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells

21 January 2018

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Signaling of DNA damage is not sufficient to induce p53 response: (re)activation of wt p53 protein strongly depends on cellular context.

21 January 2018

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Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells

21 January 2018

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Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells

21 January 2018

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Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment

21 January 2018

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Novel potent pharmacological cyclin-dependent kinase inhibitors

21 January 2018

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Adenovirus-mediated p53AIP1 gene transfer as a new strategy for treatment of p53-resistant tumors.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.22918

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13 September 2017

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