Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability (Q39642591)

13 September 2017

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability (English)

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ubiquitin-proteasome system

13 September 2017

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author name string

L Latonen

1

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13 September 2017

H M Moore

2

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13 September 2017

B Bai

3

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13 September 2017

S Jäämaa

4

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13 September 2017

M Laiho

5

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13 September 2017

language of work or name

English

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publication date

18 October 2010

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13 September 2017

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13 September 2017

30

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13 September 2017

790-805

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13 September 2017

7

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https://scigraph.springernature.com/pub.10.1038/onc.2010.469

13 September 2017

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cites work

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Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

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The multifunctional nucleolus

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PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli

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C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

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p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53.

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Nonproteolytic functions of ubiquitin in cell signaling

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Medical genetics: a marker for Stevens-Johnson syndrome

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Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo

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The dynamics of postmitotic reassembly of the nucleolus

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Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.

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Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies

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Recognition and processing of ubiquitin-protein conjugates by the proteasome

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The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

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The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

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A role for ubiquitin in the clearance of nonfunctional rRNAs

21 January 2018

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Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p

21 January 2018

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

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Nucleolus: from structure to dynamics

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Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit

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Formation of nuclear HSF1 granules varies depending on stress stimuli

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USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product

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The many pathways of RNA degradation

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CRM1-mediated nuclear export: to the pore and beyond.

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Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

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Aggresomes: a cellular response to misfolded proteins

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Proteasome inhibitors: from research tools to drug candidates

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Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement

21 January 2018

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

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Aggresomes, inclusion bodies and protein aggregation

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The function and synthesis of ribosomes.

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Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins

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p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction

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Regulation of ribosome biogenesis within the nucleolus

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

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RNA toxicity is a component of ataxin-3 degeneration in Drosophila

21 January 2018

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Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

21 January 2018

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Large-scale analysis of the human ubiquitin-related proteome

21 January 2018

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Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation

21 January 2018

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A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

21 January 2018

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The 26 S proteasome: from basic mechanisms to drug targeting

21 January 2018

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The nucleolus: an old factory with unexpected capabilities

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Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

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Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

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Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

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Directed evolution of green fluorescent protein by a new versatile PCR strategy for site-directed and semi-random mutagenesis

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21 January 2018

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Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain

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Potential roles for ubiquitin and the proteasome during ribosome biogenesis

21 January 2018

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Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway

21 January 2018

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General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants

21 January 2018

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Themes and variations on ubiquitylation

21 January 2018

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Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.469

The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.469

Tumour suppression: disruption of HAUSP gene stabilizes p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.469

Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.469

Abnormal integrity of the nucleolus associated with cell cycle arrest owing to the temperature-sensitive ubiquitin-activating enzyme E1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.469

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.469

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Dimensions Publication ID

13 September 2017

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