p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction (Q40694157)

22 September 2017

p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction (English)

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22 September 2017

Leena Latonen

1

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22 September 2017

Sari Kurki

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2

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22 September 2017

Kimmo Pitkänen

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3

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22 September 2017

Marikki Laiho

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4

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22 September 2017

1 January 2003

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22 September 2017

8

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inferred from page(s)

published in

Cellular Signalling

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22 September 2017

15

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22 September 2017

1

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22 September 2017

95-102

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Regulation of p53 downstream genes.

22 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Regulation of p53 stability

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Mechanisms of switching on p53: a role for covalent modification?

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Regulation of p53 stability by Mdm2

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

mdm2 expression is induced by wild type p53 activity

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

One-hour downward alkaline capillary transfer for blotting of DNA and RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Oncogenic forms of p53 inhibit p53-regulated gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Regulation of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

The ubiquitin-proteasome pathway: on protein death and cell life

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Stress management - heat shock protein-70 and the regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900044-X

7 January 2021

10.1016/S0898-6568(02)00044-X

Identifiers

DOI

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22 September 2017

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