The effects of zolpidem treatment and withdrawal on the in vitro expression of recombinant alpha1beta2gamma2s GABA(A) receptors expressed in HEK 293 cells. (Q39676883)

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scientific article published on 23 July 2010

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English	The effects of zolpidem treatment and withdrawal on the in vitro expression of recombinant alpha1beta2gamma2s GABA(A) receptors expressed in HEK 293 cells.	scientific article published on 23 July 2010

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8 February 2020

The effects of zolpidem treatment and withdrawal on the in vitro expression of recombinant alpha1beta2gamma2s GABA(A) receptors expressed in HEK 293 cells (English)

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8 February 2020

Josipa Vlainić

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8 February 2020

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Maja Jazvinsćak Jembrek

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8 February 2020

Dubravka Svob Strac

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8 February 2020

Danka Pericić

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8 February 2020

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23 July 2010

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8 February 2020

Naunyn-Schmiedeberg's Archives of Pharmacology

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8 February 2020

382

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8 February 2020

3

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8 February 2020

201-212

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8 February 2020

Molecular mechanisms of benzodiazepine-induced down-regulation of GABAA receptor alpha 1 subunit protein in rat cerebellar granule cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0539-0

21 January 2018

Modifications of gamma-aminobutyric acidA receptor subunit expression in rat neocortex during tolerance to diazepam.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

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Gamma-aminobutyric acidA receptor function is desensitised in rat cultured cerebellar granule cells following chronic flunitrazepam treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

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Basic pharmacologic mechanisms involved in benzodiazepine tolerance and withdrawal

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

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Chronic benzodiazepine treatment of cells expressing recombinant GABA(A) receptors uncouples allosteric binding: studies on possible mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

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Regulation of GABA(A) receptor subunit expression by pharmacological agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

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A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

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Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA(A) receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

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Sedative and anticonvulsant effects of zolpidem in adult and aged mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

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Differences in pharmacological profiles of a new generation of benzodiazepine and non-benzodiazepine hypnotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic zolpidem treatment alters GABA(A) receptor mRNA levels in the rat cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in GABA(A) receptor gene expression induced by withdrawal of, but not by long-term exposure to, zaleplon or zolpidem

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

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Chronic ethanol consumption differentially alters the expression of gamma-aminobutyric acidA receptor subunit mRNAs in rat cerebral cortex: competitive, quantitative reverse transcriptase-polymerase chain reaction analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of allosteric coupling and function of stably expressed gamma-aminobutyric acid (GABA)A receptors by chronic treatment with GABAA and benzodiazepine agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

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gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic diazepam exposure decreases transcription of the rat GABA(A) receptor gamma2-subunit gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling of alphak/gamma2 (k=1, 2, 3 and 5) interface of GABA A receptor and docking studies with zolpidem: implications for selectivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of diazepam treatment and withdrawal on recombinant GABAA receptor expression and functional coupling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic benzodiazepine agonist treatment produces functional uncoupling of the gamma-aminobutyric acid-benzodiazepine receptor ionophore complex in cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in expression of the GABA(A) receptor alpha(4) subunit gene induced by withdrawal of, but not by long-term treatment with, benzodiazepine full or partial agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zolpidem is a potent anticonvulsant in adult and aged mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-aminobutyric acidA receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Which GABAA-receptor subtypes really occur in the brain?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Aminobutyric acid-A (GABAA) agonists down-regulate GABAA/benzodiazepine receptor polypeptides from the surface of chick cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepine treatment causes uncoupling of recombinant GABAA receptors expressed in stably transfected cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of transcriptional and translational mechanisms in flumazenil-induced up-regulation of recombinant GABA(A) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

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Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology and mechanisms of action of new generation, non-benzodiazepine hypnotic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Construction and characterization of a cDNA library from 4-week-old human embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric uncoupling after chronic benzodiazepine exposure of recombinant gamma-aminobutyric acid(A) receptors expressed in Sf9 cells: ligand efficacy and subtype selectivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of zolpidem abuse and dependence: results of the French Centre for Evaluation and Information on Pharmacodependence (CEIP) network survey

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of the promoter of the human GABAA receptor alpha 1 subunit gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interactions at GABA(A) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of the hypnotic zolpidem in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic exposure of cells expressing recombinant GABAA receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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