Activation of PPARδ promotes mitochondrial energy metabolism and decreases basal insulin secretion in palmitate-treated β-cells (Q39689217)

14 September 2017

title

Activation of PPARδ promotes mitochondrial energy metabolism and decreases basal insulin secretion in palmitate-treated β-cells (English)

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14 September 2017

Li Jiang

1

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14 September 2017

Jun Wan

2

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14 September 2017

Lin-qiu Ke

3

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14 September 2017

Qing-guo Lü

4

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14 September 2017

Nan-wei Tong

5

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14 September 2017

publication date

24 June 2010

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Molecular and Cellular Biochemistry

14 September 2017

published in

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14 September 2017

volume

343

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14 September 2017

issue

1-2

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14 September 2017

page(s)

249-256

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Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.

14 September 2017

cites work

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12 December 2020

Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.

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12 December 2020

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

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12 December 2020

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

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12 December 2020

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

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12 December 2020

Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice

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12 December 2020

PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle

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12 December 2020

Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription

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12 December 2020

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

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12 December 2020

Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells

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12 December 2020

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

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12 December 2020

Regulation of muscle fiber type and running endurance by PPARdelta

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12 December 2020

PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

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12 December 2020

Energy metabolism in islets of Langerhans

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12 December 2020

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

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12 December 2020

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

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12 December 2020

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

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12 December 2020

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

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12 December 2020

Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

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12 December 2020

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

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12 December 2020

PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells.

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12 December 2020

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

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12 December 2020

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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12 December 2020

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle

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12 December 2020

Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway

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12 December 2020

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

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12 December 2020

Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation

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12 December 2020

Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet

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12 December 2020

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

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12 December 2020

Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy

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12 December 2020

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

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12 December 2020

Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis

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12 December 2020

10.1007/S11010-010-0520-8

Identifiers

DOI

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14 September 2017

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