Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. (Q45227245)

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7 January 2020

title

Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients (English)

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7 January 2020

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7

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Piero Marchetti

10

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7 January 2020

Salvatore Piro

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author name string

M Anello

1

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R Lupi

2

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7 January 2020

D Spampinato

3

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M Masini

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U Boggi

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A M Rabuazzo

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F Purrello

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7 January 2020

publication date

15 January 2005

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7 January 2020

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7 January 2020

volume

48

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7 January 2020

page(s)

282-289

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issue

2

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https://scigraph.springernature.com/pub.10.1007/s00125-004-1627-9

7 January 2020

exact match

0 references

cites work

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

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Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

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Upregulation of mitochondrial peripheral benzodiazepine receptor expression by cytokine-induced damage of human pancreatic islets

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Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio

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Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets

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Morphologic basis for loss of regulated insulin secretion by isolated rat pancreatic islets

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

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Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

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Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines

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Mitochondrial function in normal and diabetic beta-cells

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Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

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Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

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Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells.

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Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism

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Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition

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The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets

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Effects of cryopreservation and coculture with pancreatic ductal epithelial cells on insulin secretion from human pancreatic islets

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12 December 2020

Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects

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12 December 2020

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12 December 2020

10.1007/S00125-004-1627-9

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654602%20AND%20SRC:MED&resulttype=core&format=json

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7 January 2020

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