Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage (Q39705077)

14 September 2017

Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage (English)

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14 September 2017

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8

Yves Pommier

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14 September 2017

Chiara Conti

1

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14 September 2017

Elisabetta Leo

2

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14 September 2017

Gabriel S Eichler

3

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14 September 2017

Olivier Sordet

4

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14 September 2017

Melvenia M Martin

5

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14 September 2017

Angela Fan

6

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14 September 2017

Mirit I Aladjem

7

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14 September 2017

language of work or name

English

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publication date

11 May 2010

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14 September 2017

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70

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11

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14 September 2017

4470-4480

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describes a project that uses

14 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2880188/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Lysine acetylation targets protein complexes and co-regulates major cellular functions

14 September 2017

1 reference

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Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

14 September 2017

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Clinical studies of histone deacetylase inhibitors.

14 September 2017

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Histone deacetylase inhibitors: Potential in cancer therapy

14 September 2017

1 reference

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Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae

14 September 2017

1 reference

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Replicating chromatin: a tale of histones

14 September 2017

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14 September 2017

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Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways

14 September 2017

1 reference

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A dynamic stochastic model for DNA replication initiation in early embryos

14 September 2017

1 reference

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Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly

14 September 2017

1 reference

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Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.

14 September 2017

1 reference

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Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control

14 September 2017

1 reference

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The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

14 September 2017

1 reference

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Genome instability: a mechanistic view of its causes and consequences

14 September 2017

1 reference

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Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress

14 September 2017

1 reference

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The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses

14 September 2017

1 reference

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Chromatin challenges during DNA replication: a systems representation

14 September 2017

1 reference

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The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells

14 September 2017

1 reference

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Replication in context: dynamic regulation of DNA replication patterns in metazoans

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses

14 September 2017

1 reference

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Chromatin challenges during DNA replication and repair

14 September 2017

1 reference

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DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

The mammalian beta globin origin of DNA replication

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae

14 September 2017

1 reference

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The human beta-globin replication initiation region consists of two modular independent replicators

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Histone acetylation regulates the time of replication origin firing

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Dynamics of DNA replication factories in living cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Activation of dormant origins of DNA replication in budding yeast

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Chromatin replication, reconstitution and assembly

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Chromatin regulates origin activity in Drosophila follicle cells

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Visualization of altered replication dynamics after DNA damage in human cells

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880188

20 August 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20460513

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-09-3028

1 reference

14 September 2017

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14 September 2017

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