Dissecting the contribution of p16(INK4A) and the Rb family to the Ras transformed phenotype. (Q39737023)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12640134%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Dissecting the contribution of p16(INK4A) and the Rb family to the Ras transformed phenotype (English)

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1 November 2019

2

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1 November 2019

author name string

Philip J Mitchell

series ordinal

1

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1 November 2019

Denise S Malcolm

series ordinal

3

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1 November 2019

Alison C Lloyd

series ordinal

4

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1 November 2019

language of work or name

English

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publication date

1 April 2003

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Molecular and Cellular Biology

1 November 2019

published in

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1 November 2019

volume

23

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1 November 2019

issue

7

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1 November 2019

page(s)

2530-2542

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Dual inactivation of RB and p53 pathways in RAS-induced melanomas

1 November 2019

cites work

1 reference

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p16(MTS-1/CDKN2/INK4a) in cancer progression

14 September 2017

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A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

14 September 2017

1 reference

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Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.

14 September 2017

1 reference

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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

14 September 2017

1 reference

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E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control

14 September 2017

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The Rb/E2F pathway: expanding roles and emerging paradigms

14 September 2017

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p53-independent functions of the p19(ARF) tumor suppressor

14 September 2017

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Integrating the MAP kinase signal into the G1 phase cell cycle machinery

14 September 2017

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The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism

14 September 2017

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Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

14 September 2017

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Rhabdomyosarcoma--working out the pathways

14 September 2017

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The role of the J domain of SV40 large T in cellular transformation

14 September 2017

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CDK inhibitors: positive and negative regulators of G1-phase progression

14 September 2017

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A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells

14 September 2017

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

14 September 2017

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Senescence of human fibroblasts induced by oncogenic Raf.

14 September 2017

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pRB plays an essential role in cell cycle arrest induced by DNA damage

14 September 2017

1 reference

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

14 September 2017

1 reference

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Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

The regulation of E2F by pRB-family proteins

14 September 2017

1 reference

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

14 September 2017

1 reference

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Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

14 September 2017

1 reference

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p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

14 September 2017

1 reference

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Tumor-suppressive pathways in pancreatic carcinoma.

14 September 2017

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

14 September 2017

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Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

14 September 2017

1 reference

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p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen

14 September 2017

1 reference

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E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest

14 September 2017

1 reference

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Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

14 September 2017

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Association of p300 and CBP with simian virus 40 large T antigen

14 September 2017

1 reference

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The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300.

14 September 2017

1 reference

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Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

14 September 2017

1 reference

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

14 September 2017

1 reference

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14 September 2017

1 reference

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Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

14 September 2017

1 reference

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Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.

14 September 2017

1 reference

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Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.

14 September 2017

1 reference

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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Lack of replicative senescence in normal rodent glia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

DNA tumor virus transforming proteins and the cell cycle

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

The transforming activity of simian virus 40 large tumor antigen

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Dependence of cyclin E-CDK2 kinase activity on cell anchorage.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

A link between cyclin A expression and adhesion-dependent cell cycle progression

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Calcitonin gene-related peptide promotes Schwann cell proliferation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150721

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas

20 August 2018

1 reference

12 December 2020

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

1 reference

12 December 2020

Requirements for cell cycle arrest by p16INK4a

1 reference

12 December 2020

Lack of replicative senescence in cultured rat oligodendrocyte precursor cells

1 reference

12 December 2020

Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

1 reference

12 December 2020

Fibronectin and polylysine requirement for proliferation of neuroblastoma cells in defined medium

1 reference

12 December 2020

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

1 reference

12 December 2020

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1 reference

12 December 2020

10.1128/MCB.23.7.2530-2542.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12640134%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12640134%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PubMed publication ID

12640134

1 reference