Free drug concentration monitoring in clinical practice. Rationale and current status (Q39754383)

14 September 2017

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title

Free drug concentration monitoring in clinical practice. Rationale and current status (English)

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14 September 2017

C K Svensson

1

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14 September 2017

M N Woodruff

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2

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14 September 2017

J G Baxter

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3

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14 September 2017

D Lalka

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4

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14 September 2017

1 November 1986

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Clinical Pharmacokinetics

14 September 2017

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14 September 2017

11

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14 September 2017

6

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14 September 2017

450-469

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https://scigraph.springernature.com/pub.10.2165/00003088-198611060-00003

14 September 2017

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cites work

Administration of heparin causes release of non-esterified fatty acids in human plasma

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12 December 2020

Plasma protein binding of phencyclidine.

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12 December 2020

Pharmacokinetic-pharmacodynamic analysis of unbound disopyramide directly measured in serial plasma samples in man

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12 December 2020

Factors affecting quinidine protein binding in humans.

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12 December 2020

Ultrafiltration vs equilibrium dialysis for determination of free fraction.

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12 December 2020

Carbamazepine/valproic acid interaction in man and rhesus monkey

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12 December 2020

Impaired Lignocaine metabolism in patients with myocardial infarction and cardiac failure

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12 December 2020

Rapid serum lidocaine determination in the coronary care unit.

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12 December 2020

Correlation of disopyramide pharmacokinetics with efficacy in ventricular tachyarrhythmia

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12 December 2020

Pharmacokinetic studies: their role in determining therapeutic efficacy of agents designed to prevent sudden death

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12 December 2020

Clinical use and toxicity of intravenous lidocaine. A report from the Boston Collaborative Drug Surveillance Program

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12 December 2020

Diurnal fluctuations in free and total steady-state plasma levels of carbamazepine and correlation with intermittent side effects

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12 December 2020

Protein binding of diphenylhydantoin and desmethylimipramine in plasma from patients with poor renal function.

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12 December 2020

Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy

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12 December 2020

Effect of Serum Separator Blood Collection Tubes on Drug Concentrations

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12 December 2020

Evaluation of lidocaine resistance in man using intermittent large-dose infusion techniques.

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12 December 2020

Serum alpha 1-acid glycoprotein and the binding of drugs in obesity

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12 December 2020

Interaction between valproic acid and carbamazepine: an in vitro study of protein binding

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12 December 2020

Relationship between alpha 1-acid glycoprotein and plasma binding of disopyramide and mono-N-dealkyldisopyramide

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12 December 2020

The clinical value of free phenytoin levels

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12 December 2020

Spuriously low plasma propranolol concentrations resulting from blood collection methods

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12 December 2020

Kinetics and dynamics of disopyramide and its dealkylated metabolite in healthy subjects

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12 December 2020

Evaluation of methods to determine protein-binding of drugs. Equilibrium dialysis, ultrafiltration, ultracentrifugation, gel filtration

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12 December 2020

pH lability in serum during equilibrium dialysis

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12 December 2020

A possible role for cyanate in the albumin binding defect of uremia

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12 December 2020

Diphenylhydantoin side effects and serum albumin levels

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12 December 2020

Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasma

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12 December 2020

Increased alpha-1-acid glycoprotein and lidocaine disposition in myocardial infarction.

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12 December 2020

Antiarrhythmic effectiveness of intramuscular lidocaine: influence of different injection sites.

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12 December 2020

Changes in the serum alpha glycoprotein distribution in trauma patients

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12 December 2020

Protein binding of carbamazepine in epileptic patients

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12 December 2020

Aberrantly high phenytoin concentrations in saliva. Precaution in monitoring phenytoin concentrations in whole saliva

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12 December 2020

Alteration of drug-protein binding in renal disease

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12 December 2020

Role of concentration-dependent plasma protein binding in disopyramide disposition

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12 December 2020

Meperidine binding in maternal and fetal plasma

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12 December 2020

Antiepileptic Drug Monitoring by Chromatographic Methods and Immunotechniques—Comparison of Analytical Performance, Practicability, and Economy

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12 December 2020

Utility of free level monitoring of antiepileptic drugs

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12 December 2020

Binding of prednisolone to alpha 1-acid glycoprotein

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12 December 2020

Drug binding in the undernourished: a study of the binding of propranolol to alpha 1-acid glycoprotein

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12 December 2020

Plasma protein carbamylation and decreased acidic drug protein binding in uremia

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12 December 2020

Regional myocardial lidocaine concentration determines the antidysrhythmic effect in dogs after coronary artery occlusion.

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12 December 2020

Possible hazard of valpromide-carbamazepine combination therapy in epilepsy

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12 December 2020

Protein binding of drugs in plasma from patients with acute renal failure.

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12 December 2020

The displacing effect of a fatty acid on the binding of diazepam to human serum albumin

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12 December 2020

Plasma protein binding of drugs as influenced by blood collection methods

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12 December 2020

The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study.

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12 December 2020

Determination of unbound valproic acid concentration in plasma by equilibrium dialysis and gas--liquid chromatography: methodological aspects and observations in epileptic patients

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12 December 2020

Anticonvulsant Level in Saliva, Serum, and Cerebrospinal Fluid

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12 December 2020

Effects of aspirin on salivary and serum phenytoin kinetics in healthy subjects

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12 December 2020

Plasma protein binding of carbamazepine

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12 December 2020

Plasma protein binding of basic drugs. II. Importance of alpha 1-acid glycoprotein for interindividual variation

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12 December 2020

The effects of age and smoking on the plasma protein binding of lignocaine and diazepam

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12 December 2020

Monitoring phenytoin in salivary and plasma ultrafiltrates of pediatric patients

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12 December 2020

Binding of anilide-type local anesthetics in human plasma. I. Relationships between binding, physicochemical properties, and anesthetic activity.

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12 December 2020

Effects of cancer and its treatments on plasma concentration of alpha 1-acid glycoprotein and propranolol binding

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12 December 2020

Optical studies on the specific interaction of dipyridamole with α1-acid glycoprotein (orosomucoid)

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12 December 2020

Elimination and serum protein binding of phenylbutazone in patients with renal insufficiency

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12 December 2020

Carbamazepine plasma levels in children and adults: influence of age, dose, and associated therapy

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12 December 2020

Gas chromatography versus immunoassay (EMIT) for analysis of free phenytoin in serum ultrafiltrate

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12 December 2020

Plasma concentrations of unbound phenytoin in the management of epilepsy

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12 December 2020

Interactions of phenobarbital with propranolol in the dog. 1. Plasma protein binding

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12 December 2020

The binding of chloramphenicol to serum proteins in patients with chronic renal insufficiency

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12 December 2020

Antiarrhythmic and electrocardiographic effects of single oral doses of disopyramide

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12 December 2020

Saliva carbamazepine levels in children

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12 December 2020

Altered drug binding due to the use of indwelling heparinized cannulas (heparin lock) for sampling

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12 December 2020

Effect of dose increments on serum carbamazepine concentration in epileptic patients

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12 December 2020

Prolonged variability in plasma protein binding of disopyramide after acute myocardial infarction

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12 December 2020

Disopyramide pharmacokinetics and bioavailability following the simultaneous administration of disopyramide and 14C-disopyramide

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12 December 2020

Comparison of Assay Methods Used to Measure Antiepileptic Drugs in Plasma

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12 December 2020

Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans

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12 December 2020

Free fraction of valproic acid: in vitro time-dependent increase and correlation with free fatty acid concentration in human plasma and serum

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12 December 2020

Serum Concentrations of Free Diphenylhydantoin and their Relationship To Clinical Intoxication

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12 December 2020

Concentration-effect relationships of valproic acid

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12 December 2020

Antiepileptic drugs and alpha 1-acid glycoprotein

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12 December 2020

Salivary concentrations and plasma protein binding of carbamazepine and carbamazepine 10,11-epoxide in epileptic patients

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12 December 2020

Alpha-1-acid Glycoprotein and Beta-endorphin Alterations in Chronic Pain Patients

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12 December 2020

Plasma protein binding of drugs after severe burn injury.

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12 December 2020

The influence of cirrhosis on steady-state blood concentrations of unbound propranolol after oral administration

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12 December 2020

Single-drug therapy with carbamazepine in patients with epilepsy: serum levels and clinical effect.

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12 December 2020

Effect of Lidocaine on Ventricular Arrhythmias in Patients with Coronary Heart Disease

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12 December 2020

Protein binding of valproic acid in uremic patients

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12 December 2020

Factors influencing the relationship between carbamazepine plasma concentration and its clinical effects in patients with epilepsy.

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12 December 2020

Relationship between Quinidine Plasma and Saliva Levels in Humans

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12 December 2020

Plasma protein binding of diphenylhydantoin in normal and hyperbilirubinemic infants

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12 December 2020

The "ultra-free" ultrafiltration technique compared with equilibrium dialysis for determination of unbound thiopental concentrations in serum.

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12 December 2020

Increased plasma binding of quinidine after surgery: a preliminary report

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12 December 2020

pH‐Dependent Secretion of Procainamide into Saliva

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12 December 2020

Increase of alpha 1-acid glycoprotein after treatment with amitriptyline

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12 December 2020

Abnormal serum protein binding of acidic drugs in diabetes mellitus.

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12 December 2020

Hepatic enzyme induction and leucocyte delta-aminolaevulinic acid synthase activity: studies with carbamazepine

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12 December 2020

Characterization of a common binding site for basic drugs on human alpha 1-acid glycoprotein (orosomucoid)

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12 December 2020

Disopyramide: serum level and arrhythmia conversion

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12 December 2020

Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans

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12 December 2020

Alpha1-acid glycoprotein concentration and protein binding in trauma.

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12 December 2020

Fallacious results from measuring salivary carbamazepine concentrations

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12 December 2020

Effects of contaminants in blood-collection devices on measurements of therapeutic drugs.

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12 December 2020

Pethidine binding to blood cells and plasma proteins in old and young subjects

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12 December 2020

Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution

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12 December 2020

Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide.

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12 December 2020

Free level monitoring of antiepileptic drugs. Clinical usefulness and case studies

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12 December 2020

Free level monitoring of carbamazepine and valproic acid: clinical significance

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12 December 2020

Factors influencing the apparent protein binding of quinidine

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12 December 2020

Characterization of drug-protein interactions by classic methods

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12 December 2020

Effect of intra-individual change in serum protein binding on the pharmacologic response of R- and S-disopyramide in the rabbit

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12 December 2020

Plasma Protein Binding of Thiopental in Patients with Impaired Renal or Hepatic Function

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12 December 2020

Isolation and chemical characterization of 2-hydroxybenzoylglycine as a drug binding inhibitor in uremia

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12 December 2020

Protein binding of several drugs in serum and plasma of healthy subjects

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12 December 2020

Concentration-dependence of disopyramide binding to plasma protein and its influence on kinetics and dynamics

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12 December 2020

Stereoselective pharmacokinetics of disopyramide enantiomers in man

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12 December 2020

The EMIT FreeLevel ultrafiltration technique compared with equilibrium dialysis and ultracentrifugation to determine protein binding of phenytoin

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12 December 2020

Salivary phenytoin concentrations in epilepsy and in chronic renal failure

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12 December 2020

Lignocaine disposition in blood in epilepsy

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12 December 2020

Metabolite interference in homogeneous enzyme immunoassay of phenytoin

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12 December 2020

Diurnal variation of alpha 1-acid glycoprotein concentration in normal volunteers.

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12 December 2020

Evidence for binding of certain acidic drugs to alpha 1-acid glycoprotein

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12 December 2020

Clinical pharmacokinetics of disopyramide

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12 December 2020

Factors influencing serum protein binding of lidocaine in humans.

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12 December 2020

Plasma Albumin Concentration and Diphenylhydantoin Binding in Man

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12 December 2020

Displacement of lidocaine from serum alpha 1-acid glycoprotein binding sites by basic drugs.

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12 December 2020

Kinetics of Hemodynamic and Electrocardiographic Changes Following Intravenous Disopyramide

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12 December 2020

Steady-state serum levels of quinidine and active metabolites in cardiac patients with varying degrees of renal function

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12 December 2020

Influence of long-term infusions on lidocaine kinetics.

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12 December 2020

Influence of Blood Sampling Methods on Dopamine-Receptor-Blocking Activities as Determined by a Radioreceptor Assay

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12 December 2020

Gas-chromatographic assay of free phenytoin in ultrafiltrates of plasma: test of a new filtration apparatus and specimen stability.

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12 December 2020

Plasma protein binding of disopyramide by equilibrium dialysis and ultrafiltration

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12 December 2020

Effect of altered disopyramide binding on its pharmacologic response in rabbits

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12 December 2020

Saliva concentrations of lidocaine and its metabolites in man.

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12 December 2020

Anticonvulsant drugs. An update

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12 December 2020

Mechanism of anticonvulsant action of valproate

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12 December 2020

Isolation of peptides from uremic plasma that inhibit phenytoin binding to normal plasma proteins

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12 December 2020

The effects of urine pH and plasma protein binding on the renal clearance of disopyramide

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12 December 2020

Drug interactions with valproic acid

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12 December 2020

Potent therapeutic effect of carbamazepine-10,11-epoxide in trigeminal neuralgia

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12 December 2020

Carbamazepine--A double-blind comparison with phenytoin

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12 December 2020

Binding of amobarbital, pentobarbital and diphenylhydantoin to blood cells and plasma proteins in healthy volunteers and uraemic patients

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12 December 2020

Increased plasma propranolol binding in myocardial infarction

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12 December 2020

Spuriously high values of unbound drug fraction in serum as determined by the new ultrafree anticonvulsant drug filters [letter]

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12 December 2020

Effect of Concentration-Dependent Binding to Plasma Proteins on the Pharmacokinetics and Pharmacodynamics of Disopyramide

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12 December 2020

Plasma protein binding of phenytoin in 100 epileptic patients

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12 December 2020

Sequential changes of plasma proteins after surgical trauma.

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12 December 2020

Effects of caffeine on plasma free fatty acids, urinary catecholamines, and drug binding.

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12 December 2020

Quantitative analysis of the disopyramide concentration-effect relationship

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12 December 2020

Bupivacaine protein binding in the term parturient: effects of lactic acidosis.

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12 December 2020

Determinants of carbamazepine and carbamazepine 10,11-epoxide binding to serum protein, albumin and alpha 1-acid glycoprotein

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12 December 2020

Blood collection techniques, heparin and quinidine protein binding

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12 December 2020

Altered plasma drug binding in cancer: role of alpha 1-acid glycoprotein and albumin.

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12 December 2020

Continuous infusion of lidocaine in patients with cardiac arrhythmias. Unpredictability of plasma concentrations.

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12 December 2020

Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal and hepatic disease.

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12 December 2020

The alteration of plasma proteins in uremia as reflected in the ability to bind diphenylhydantoin

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12 December 2020

Effect of smoking on binding of lidocaine to human serum proteins.

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12 December 2020

Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide

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12 December 2020

Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects

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12 December 2020

Determination of total and free plasma carbamazepine concentrations by enzyme multiplied immunoassay: interference with the 10,11-epoxide metabolite

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12 December 2020

Phenytoin pharmacokinetics in burned rats and plasma protein binding of phenytoin in burned patients

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12 December 2020

Protein binding and drug clearance

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12 December 2020

Influence of congestive heart failure on blood levels of lidocaine and its active monodeethylated metabolite

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12 December 2020

Plasma protein binding and therapeutic drug monitoring

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12 December 2020

Effect of heparin and fatty acids on the binding of quinidine and warfarin in plasma

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12 December 2020

Inhibitor of drug-protein binding in "Vacutainers"

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12 December 2020

Effects of carbamylation of plasma proteins and competitive displacers on drug binding in uremia.

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12 December 2020

Assessment of blood collection systems for the high performance liquid chromatography measurement of propranolol.

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12 December 2020

Multiple bolus technique for lidocaine administration during the first hours of an acute myocardial infarction

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12 December 2020

Plasma binding and disposition of furosemide in the nephrotic syndrome and in uremia

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12 December 2020

Phencyclidine blood protein binding: influence of protein, pH and species

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12 December 2020

Dose-Dependency of the Ratio Between Carbamazepine Serum Level and Dosage in Patients with Epilepsy

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12 December 2020

Measurement of drugs in saliva: a review

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12 December 2020

Effect of disopyramide on left ventricular performance: the relationship of free and total concentrations of the drug and of its mono-N-dealkylated metabolite to noninvasive indices of function

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12 December 2020

Effect of late pregnancy on salicylate, diazepam, warfarin, and propranolol binding: use of fluorescent probes.

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12 December 2020

Free and total plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients: diurnal fluctuations and relationship with side effects.

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12 December 2020

Plasma binding of disopyramide and mono-N-dealkyldisopyramide

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12 December 2020

Equilibrium dialysis, ultrafiltration, and ultracentrifugation compared for determining the plasma-protein-binding characteristics of valproic acid.

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12 December 2020

Plasma binding variations of amitriptyline and nortriptyline

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12 December 2020

Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins

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12 December 2020

Decreased alpha 1-acid glycoprotein in liver cirrhosis: consequences for drug protein binding

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12 December 2020

Plasma and Tissue Binding Considerations in Drug Disposition

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12 December 2020

Disopyramide serum and pharmacologic effect kinetics applied to the assessment of bioavailability

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12 December 2020

Clinical pharmacokinetics of valproic acid

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12 December 2020

Theophylline disposition in patients with hepatic cirrhosis

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12 December 2020

Monitoring of free valproic acid levels?

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12 December 2020

Liquid chromatography and fluorescence spectroscopy compared with a homogeneous enzyme immunoassay technique for determining quinidine in serum

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12 December 2020

Plasma protein binding of etidocaine during pregnancy and labour.

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12 December 2020

Binding and Displacement of Basic, Acidic and Neutral Drugs in Normal and Orosomucoid-deficient Plasma

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12 December 2020

The place of saliva in antiepileptic drug monitoring

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12 December 2020

Increased Plasma Protein Binding of Propranolol and Chlorpromazine Mediated by Disease-Induced Elevations of Plasma α1Acid Glycoprotein

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12 December 2020

Pharmacokinetics of lidocaine after prolonged intravenous infusions in uncomplicated myocardial infarction.

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12 December 2020

Contribution of 5-(4-Hydroxyphenyl)-5-phenylhydantoin to the Discrepancy Between Phenytoin Analyses by EMIT and High-Pressure Liquid Chromatography

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12 December 2020

High-dose monotherapy in treatment of intractable seizures

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12 December 2020

Plasma concentrations and protein binding of disopyramide and mono-N-dealkyldisopyramide during chronic oral disopyramide therapy

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12 December 2020

Clinical Pharmacokinetics of Carbamazepine

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12 December 2020

Diazepam and lidocaine plasma protein binding in renal disease.

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12 December 2020

Enzyme induction with rifampicin; lipoproteins and drug binding to alpha 1-acid glycoprotein

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12 December 2020

Endogenous accumulation products and serum protein binding in uremia

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12 December 2020

Plasma levels, protein binding, and elimination data of lidocaine and active metabolites in cardiac patients of various ages

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12 December 2020

Binding of?-adrenoceptor blocking drugs to human serum albumin, to ?1-acid glycoprotein and to human serum

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12 December 2020

Should we routinely measure free plasma phenytoin concentration?

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12 December 2020

Treatment of Intractable Neurogenic Pain with Carbamazepine

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12 December 2020

Decreased plasma protein binding of diazoxide in uremia

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12 December 2020

Serum disopyramide concentrations and suppression of ventricular premature contractions.

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12 December 2020

Lidocaine efficacy and toxicity assessed by a new, rapid method.

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12 December 2020

Factors affecting the measurement of lidocaine protein binding by equilibrium dialysis in human serum.

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12 December 2020

Monitoring free plasma concentrations of phenytoin

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12 December 2020

Aromatic amino acid metabolites as potential protein binding inhibitors in human uremic plasma.

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12 December 2020

Clinical implications of serum protein binding in epileptic children during sodium valproate maintenance therapy.

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12 December 2020

Methadone plasma protein binding: alterations in cancer and displacement from alpha 1-acid glycoprotein

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12 December 2020

Lidocaine plasma protein binding.

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12 December 2020

Diphenylhydantoin: Correlation between protein binding and albumin concentration

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12 December 2020

The Stereoselective Disposition of Disopyramide in the Dog

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12 December 2020

Effect of age and plasma concentrations of albumin and alpha 1-acid glycoprotein on protein binding of disopyramide

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12 December 2020

Relationship between alpha 1-acid glycoprotein and lidocaine disposition in myocardial infarction.

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12 December 2020

Influence of chronic renal failure and hemodialysis on diflunisal plasma protein binding

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12 December 2020

Impaired plasma protein binding of phenytoin in uremia and displacement effect of salicylic acid

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12 December 2020

The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide

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12 December 2020

Therapeutic Drug Monitoring in Saliva

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12 December 2020

10.2165/00003088-198611060-00003

Identifiers

DOI

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Dimensions Publication ID

14 September 2017

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