Anti-tumor activity and mechanisms of a novel vascular disrupting agent, (Z)-3,4',5-trimethoxylstilbene-3'-O-phosphate disodium (M410). (Q39763075)

14 September 2017

title

Anti-tumor activity and mechanisms of a novel vascular disrupting agent, (Z)-3,4',5-trimethoxylstilbene-3'-O-phosphate disodium (M410). (English)

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14 September 2017

Yu-Chen Cai

1

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14 September 2017

Yong Zou

2

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14 September 2017

Yan-Li Ye

3

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14 September 2017

Hong-Yi Sun

4

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14 September 2017

Quan-Guan Su

5

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14 September 2017

Zhi-Xin Wang

6

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14 September 2017

Zhao-Lei Zeng

7

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14 September 2017

Li-Jian Xian

8

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14 September 2017

publication date

11 December 2009

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Investigational New Drugs

14 September 2017

published in

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14 September 2017

volume

29

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14 September 2017

issue

2

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14 September 2017

page(s)

300-311

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Tumor angiogenesis: therapeutic implications

14 September 2017

cites work

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Signaling angiogenesis via p42/p44 MAP kinase and hypoxia

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Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.

21 January 2018

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Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status

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Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results

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In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug

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Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy

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Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization

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Synthesis and anti-tumor activity of novel combretastatins: combretocyclopentenones and related analogues

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Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression

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Oxygen sensing and molecular adaptation to hypoxia

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12 December 2020

ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature.

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Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

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12 December 2020

Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.

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Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins

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Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (Taxotere): association with impaired repositioning of the microtubule organizing center

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Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer

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Vascular-targeting activity of ZD6126, a novel tubulin-binding agent.

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Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy

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12 December 2020

The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability.

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12 December 2020

Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer.

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Combretastatin A4 prodrug study of effect on the growth and the microvasculature of colorectal liver metastases in a murine model

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12 December 2020

Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo

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12 December 2020

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

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12 December 2020

Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs

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12 December 2020

Vascular endothelial growth factor (VEGF) and its effect on angiogenesis

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12 December 2020

Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate

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12 December 2020

Involvement of hypoxia-inducible factor 1 in human cancer

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12 December 2020

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature

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12 December 2020

Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.

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12 December 2020

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12 December 2020

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12 December 2020

10.1007/S10637-009-9366-X

Identifiers

DOI

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14 September 2017

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