Rictor is a novel target of p70 S6 kinase-1. (Q39771171)

14 September 2017

Rictor is a novel target of p70 S6 kinase-1. (English)

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14 September 2017

3

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5

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C Treins

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14 September 2017

P H Warne

series ordinal

2

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14 September 2017

M Pende

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4

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14 September 2017

language of work or name

English

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publication date

23 November 2009

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14 September 2017

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29

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1003-1016

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https://scigraph.springernature.com/pub.10.1038/onc.2009.401

14 September 2017

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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

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A quantitative atlas of mitotic phosphorylation

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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Defining the role of mTOR in cancer

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mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

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The 14-3-3 cancer connection

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Signaling by target of rapamycin proteins in cell growth control

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1

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Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

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Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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Molecular mechanisms of mTOR-mediated translational control

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Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

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Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

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Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

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SKAR is a specific target of S6 kinase 1 in cell growth control

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Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

21 January 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Identification of a conserved motif required for mTOR signaling

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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

21 January 2018

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

21 January 2018

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation

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TOR signaling in growth and metabolism

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The structural basis for 14-3-3:phosphopeptide binding specificity

21 January 2018

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

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Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry

21 January 2018

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.401

Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.401

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.401

1 reference

14 September 2017

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