Transcriptome profiling of a TGF-beta-induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies. (Q39771195)

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English	Transcriptome profiling of a TGF-beta-induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies.	scientific article

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12 February 2020

Transcriptome profiling of a TGF-beta-induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies (English)

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12 February 2020

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12 February 2020

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A E G Lenferink

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C Cantin

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A Nantel

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E Wang

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Y Durocher

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12 February 2020

M Banville

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B Paul-Roc

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12 February 2020

M D O'Connor-McCourt

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23 November 2009

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12 February 2020

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12 February 2020

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12 February 2020

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12 February 2020

831-844

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12 February 2020

https://scigraph.springernature.com/pub.10.1038/onc.2009.399

0 references

Clusterin activates survival through the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin expression in normal mucosa and colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

TGF-beta and BMP7 interactions in tumour progression and bone metastasis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin silencing in human lung adenocarcinoma cells induces a mesenchymal-to-epithelial transition through modulating the ERK/Slug pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Differential regulation of clusterin and its isoforms by androgens in prostate cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Autocrine transforming growth factor-beta signaling mediates Smad-independent motility in human cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Intrinsically disordered protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Cluster analysis and display of genome-wide expression patterns

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Stress-induced gene expression in Candida albicans: absence of a general stress response.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Specificity and versatility in tgf-beta signaling through Smads

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Ram rete testis fluid contains a protein (clusterin) which influences cell-cell interactions in vitro

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Use of antisense oligonucleotides targeting the antiapoptotic gene, clusterin/testosterone-repressed prostate message 2, to enhance androgen sensitivity and chemosensitivity in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Modulation of markers associated with aggressive phenotype in MDA-MB-231 breast carcinoma cells by sulforaphane

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Regulation of clusterin gene expression by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Transforming growth factor beta regulates clusterin gene expression via modulation of transcription factor c-Fos

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Evidence that clusterin has discrete chaperone and ligand binding sites.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

A novel orthotopic model of breast cancer metastasis to bone.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Investigation of three new mouse mammary tumor cell lines as models for transforming growth factor (TGF)-beta and Neu pathway signaling studies: identification of a novel model for TGF-beta-induced epithelial-to-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Synthesis and functional analyses of nuclear clusterin, a cell death protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Genes that mediate breast cancer metastasis to lung

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Introducing the clusterin gene into human renal cell carcinoma cells enhances their metastatic potential

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin isoforms differentially affect growth and motility of prostate cells: possible implications in prostate tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Genetic determinants of cancer metastasis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Overexpression of clusterin in human breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Systematic variation in gene expression patterns in human cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin overexpression in both malignant and nonmalignant prostate epithelial cells induces cell cycle arrest and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Adaptation versus selection: the origins of metastatic behavior

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Mechanisms of the development of androgen independence in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Antisense oligonucleotide therapy in the management of bladder cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Knockdown of the cytoprotective chaperone, clusterin, chemosensitizes human breast cancer cells both in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

The fallacy of epithelial mesenchymal transition in neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Epithelial-mesenchymal transitions in development and pathologies

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Advances and challenges in basic and translational research on clusterin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin/apolipoprotein J in human aging and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Differential effects of clusterin/apolipoprotein J on cellular growth and survival.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Significance analysis of microarrays applied to the ionizing radiation response

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

TGF-beta signaling: positive and negative effects on tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin is a secreted mammalian chaperone

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Direct regulation of TWIST by HIF-1alpha promotes metastasis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Clusterin plays an important role in hepatocellular carcinoma metastasis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

21 January 2018

Black cellular spreading and motility assay

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

31 March 2020

A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

31 March 2020

Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

31 March 2020

Clusterin is an extracellular chaperone that specifically interacts with slowly aggregating proteins on their off-folding pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

31 March 2020

Cytotoxic sensitivity to tumor necrosis factor-alpha in PC3 and LNCaP prostatic cancer cells is regulated by extracellular levels of SGP-2 (clusterin).

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

31 March 2020

Transforming growth factor beta-1 up-regulates clusterin synthesis in thyroid epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

31 March 2020

Clusterin binds by a multivalent mechanism to the Fc and Fab regions of IgG

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.399

31 March 2020

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